GM-CSF-Dependent Inflammatory Pathways.
Autoimmunity
/ immunology
Cytokines
/ immunology
Dendritic Cells
/ immunology
Granulocyte-Macrophage Colony-Stimulating Factor
/ immunology
Humans
Inflammation
/ immunology
Macrophages
/ immunology
Monocytes
/ immunology
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
/ immunology
Signal Transduction
/ immunology
CCL17
IRF4
cell survival
inflammation
pain
polarization
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
03
2019
accepted:
14
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Pre-clinical models and clinical trials demonstrate that targeting the action of the cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), can be efficacious in inflammation/autoimmunity reinforcing the importance of understanding how GM-CSF functions; a significant GM-CSF-responding cell in this context is likely to be the monocyte. This article summarizes critically the literature on the downstream cellular pathways regulating GM-CSF interaction with monocytes (and macrophages), highlighting some contentious issues, and conclusions surrounding this biology. It also suggests future directions which could be undertaken so as to more fully understand this aspect of GM-CSF biology. Given the focus of this collection of articles on monocytes, the following discussion in general will be limited to this population or to its more mature progeny, the macrophage, even though GM-CSF biology is broader than this.
Identifiants
pubmed: 31552022
doi: 10.3389/fimmu.2019.02055
pmc: PMC6737278
doi:
Substances chimiques
Cytokines
0
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
0
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2055Références
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