Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?
Adaptive Immunity
Autoimmune Diseases
/ etiology
Autoimmunity
Biomarkers
Blood-Brain Barrier
/ metabolism
Central Nervous System
/ immunology
Disease Susceptibility
/ immunology
Encephalitis
/ etiology
Hashimoto Disease
/ etiology
Humans
Immunity, Innate
Microglia
/ immunology
Monocytes
/ immunology
autoimmune encephalitis
blood brain barrier
epilepsy
innate immunity
microglia
monocytes
neuroimmunology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
05
2019
accepted:
15
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The autoimmune encephalitides are a group of autoimmune conditions targeting the central nervous system and causing severe clinical symptoms including drug-resistant seizures, cognitive dysfunction and psychiatric disturbance. Although these disorders appear to be antibody mediated, the role of innate immune responses needs further clarification. Infiltrating monocytes and microglial proliferation at the site of pathology could contribute to the pathogenesis of the disease with resultant blood brain barrier dysfunction, and subsequent activation of adaptive immune response. Both innate and adaptive immune cells can produce pro-inflammatory molecules which can perpetuate ongoing neuroinflammation and drive ongoing seizure activity. Ultimately neurodegenerative changes can ensue with resultant long-term neurological sequelae that can impact on ongoing patient morbidity and quality of life, providing a potential target for future translational research.
Identifiants
pubmed: 31552027
doi: 10.3389/fimmu.2019.02066
pmc: PMC6746826
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2066Références
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