The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.
Basoph8
basophil
depletion
flow cytometry
phenotype
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
05
2019
accepted:
27
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage phenotype. Here, we show that the expression of basophils lineage markers CD200R3 and FcεRIα is highly variable in inflammatory settings and hinders basophils identification by flow cytometry across multiple disease states or tissues. Fluorophore-conjugated antibody staining of these lineage markers strongly activates basophil type 2 cytokine expression, and represents a potential bias for coculture or
Identifiants
pubmed: 31552058
doi: 10.3389/fimmu.2019.02143
pmc: PMC6746837
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2143Références
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