Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival.
atypical CTC
circulating tumor cells
digital droplet PCR
gene signature
overall survival
pancreatic cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
06
2019
accepted:
22
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
26
9
2019
Statut:
epublish
Résumé
The interest in liquid biopsy is growing because it could represent a non-invasive prognostic or predictive tool for clinical outcome in patients with pancreatic ductal adenocarcinoma (PDAC), an aggressive and lethal disease. In this pilot study, circulating tumor cells (CTCs), CD16 positive atypical CTCs, and CTC clusters were captured and characterized in the blood of patients with PDAC before and after palliative first line chemotherapy by ScreenCell device, immunohistochemistry, and confocal microscopy analysis. Gene profiles were performed by digital droplet PCR in isolated CTCs, five primary PDAC tissues, and three different batches of RNA from normal human pancreatic tissue. Welsh's
Identifiants
pubmed: 31552188
doi: 10.3389/fonc.2019.00874
pmc: PMC6746928
doi:
Types de publication
Journal Article
Langues
eng
Pagination
874Références
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