Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
Amino Acid Transport System A
/ antagonists & inhibitors
Animals
Autophagy
/ drug effects
Cerebral Infarction
/ etiology
Gene Expression
Genetic Loci
Genome
Immunohistochemistry
Mice
Mice, Knockout
Neurons
/ drug effects
Neuroprotection
Neuroprotective Agents
/ pharmacology
Organ Specificity
TOR Serine-Threonine Kinases
/ metabolism
Cell death in the nervous system
Neurodegeneration
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
08
2018
accepted:
19
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
26
9
2019
Statut:
epublish
Résumé
The pathophysiological role of mammalian target of rapamycin complex 1 (mTORC1) in neurodegenerative diseases is established, but possible therapeutic targets responsible for its activation in neurons must be explored. Here we identified solute carrier family 38a member 1 (SNAT1,
Identifiants
pubmed: 31552299
doi: 10.1038/s42003-019-0582-4
pii: 582
pmc: PMC6751179
doi:
Substances chimiques
Amino Acid Transport System A
0
Neuroprotective Agents
0
Slc38a1 protein, mouse
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
346Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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