Acute kidney injury during an ultra-distance race.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
06
2019
accepted:
30
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
11
3
2020
Statut:
epublish
Résumé
Previous studies have noted consequences of ultra-distance trail running on health, but few studies are available regarding the temporal variations of renal biomarker injury during the running. The aim of this study was to assess the of kidney function parameters temporal variation during and on short-term after an ultra-distance race. We performed an observational study with 47 subjects participating in an ultra-distance race (80 km). Urine (47 subjects) and blood (21 subjects) samples were serially collected before (baseline-km 0), during (21 and 53 km), on arrival (80 km), and 9 days after the race (d9). Mean serum creatinine increased during the race from 90±14 μmol/L (km0) to 136±32 μmol/L (km 80-p<0.0001) corresponding to a 52% increase. Mean creatininuria progressively increased from 4.7±4.5 mmol/L (km 0) to 22.8±12.0 mmol/L (km 80) (p<0.0001). Both urinary biomarkers (Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1) of acute kidney injury (AKI) progressively increased during the race (p<0.05 vs baseline). However, after adjustment to urine dilution by urine creatinine, no significant changes remained (p>0.05). On day 9, no significant difference remains in blood and urine biomarkers compared to their respective baseline levels. During an ultra-distance race, despite an acute and transient increase in the serum creatinine levels, urinary biomarkers of AKI displayed only limited changes with a complete regression on day 9. These results suggest the absence of the short-term impact of an ultra-distance race kidney function.
Identifiants
pubmed: 31553742
doi: 10.1371/journal.pone.0222544
pii: PONE-D-19-17069
pmc: PMC6760777
doi:
Substances chimiques
Biomarkers
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0222544Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur J Clin Invest. 2003 Aug;33(8):726-30
pubmed: 12864784
S Afr Med J. 2000 Jan;90(1):39-40
pubmed: 10721387
Clin Transl Sci. 2008 Dec;1(3):200-8
pubmed: 19212447
Circ Cardiovasc Imaging. 2011 May;4(3):253-63
pubmed: 21421670
Kidney Int. 2010 Sep;78(5):486-94
pubmed: 20555318
Kidney Int. 2012 Mar;81(5):477-85
pubmed: 22157656
Kidney Int. 2017 Aug;92(2):440-452
pubmed: 28416224
Kidney Int. 2000 Jun;57(6):2423-33
pubmed: 10844611
Kidney Int. 2005 Jun;67(6):2089-100
pubmed: 15882252
Kidney Int. 2011 Aug;80(4):405-14
pubmed: 21412214
JAMA. 2009 Sep 16;302(11):1179-85
pubmed: 19755696
Clin J Am Soc Nephrol. 2011 Oct;6(10):2347-55
pubmed: 21885792
Nephron. 1993;64(1):119-21
pubmed: 8502316
Clin J Am Soc Nephrol. 2011 Nov;6(11):2567-72
pubmed: 21903988
Nephrology (Carlton). 2011 Feb;16(2):194-9
pubmed: 21272132
Pediatr Nephrol. 2016 Dec;31(12):2353-2363
pubmed: 27286687
N Engl J Med. 2014 Jul 3;371(1):58-66
pubmed: 24988558
Intern Med J. 2015 Jan;45(1):74-9
pubmed: 25371101
Clin J Am Soc Nephrol. 2008 May;3(3):665-73
pubmed: 18337554
Visc Med. 2016 Jun;32(3):199-204
pubmed: 27493948
Med Sci Sports Exerc. 2009 Jan;41(1):26-34
pubmed: 19092706
Eur J Appl Physiol. 2007 Mar;99(4):443-7
pubmed: 17206443
Nephron Clin Pract. 2012;120(4):c179-84
pubmed: 22890468
Transplantation. 2017 Feb;101(2):387-394
pubmed: 26901081
J Am Coll Cardiol. 2011 Apr 26;57(17):1752-61
pubmed: 21511111
Kidney Int. 2012 Mar;81(5):442-8
pubmed: 22113526
Clin Chem Lab Med. 2012 Feb 14;50(9):1585-9
pubmed: 22962218
J Am Coll Cardiol. 2012 Jan 17;59(3):246-55
pubmed: 22240130
Am J Med. 1998 Sep;105(3):251-2
pubmed: 9753030
Kidney Blood Press Res. 2018;43(4):1255-1262
pubmed: 30078006
Am J Cardiol. 2015 Oct 15;116(8):1284-9
pubmed: 26294134
Acta Physiol (Oxf). 2013 Apr;207(4):700-8
pubmed: 23336369
PLoS One. 2014 Nov 17;9(11):e113006
pubmed: 25402277
Med Sci Sports Exerc. 2013 Nov;45(11):2072-9
pubmed: 23657162
Eur J Pediatr. 2017 Jun;176(6):745-755
pubmed: 28409285
Shock. 2016 Jul;46(1):44-51
pubmed: 26849631
Circulation. 2010 Aug 17;122(7):743-52
pubmed: 20713909
Exp Biol Med (Maywood). 2003 Nov;228(10):1208-12
pubmed: 14610262
Chin J Physiol. 2018 Mar 12;61(2):85-91
pubmed: 29526077
Am J Kidney Dis. 2017 Jan;69(1):18-28
pubmed: 27555107
J Am Soc Nephrol. 2009 Jan;20(1):223-8
pubmed: 19020007