Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity.
CD103
DC
IBD
PD1
PDL1
PDL2
Smad7
TGF-β
Treg
UC
dendritic cell
inflammatory bowel disease
ulcerative colitis
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
24 09 2019
24 09 2019
Historique:
received:
23
10
2018
revised:
09
06
2019
accepted:
18
07
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
ppublish
Résumé
Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC). Here, we found that Smad7 mediates intestinal inflammation by limiting the PDL2/1-PD1 axis in dendritic cells (DCs) and CD4
Identifiants
pubmed: 31553906
pii: S2211-1247(19)30969-6
doi: 10.1016/j.celrep.2019.07.065
pmc: PMC6925592
mid: NIHMS1543789
pii:
doi:
Substances chimiques
SMAD7 protein, human
0
Smad7 Protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3353-3366.e5Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127853
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151953
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA267479
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI174047
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Références
J Clin Invest. 2009 Sep;119(9):2441-50
pubmed: 19729841
Brain. 2010 Apr;133(Pt 4):1067-81
pubmed: 20354004
Clin Exp Immunol. 2010 Oct;162(1):1-11
pubmed: 20682002
J Crohns Colitis. 2017 May 1;11(5):603-609
pubmed: 28453765
J Immunol. 2004 May 1;172(9):5149-53
pubmed: 15100250
J Clin Immunol. 2010 Jan;30(1):80-9
pubmed: 19936899
Nat Rev Immunol. 2016 May;16(5):295-309
pubmed: 27087661
Gastroenterology. 2011 Nov;141(5):1802-12
pubmed: 21723222
Curr Protoc Immunol. 2014 Feb 04;104:15.25.1-15.25.14
pubmed: 24510619
N Engl J Med. 2015 Mar 19;372(12):1104-13
pubmed: 25785968
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11695-700
pubmed: 16864790
Cold Spring Harb Perspect Biol. 2013 Jul 01;5(7):null
pubmed: 23818502
Immunology. 2017 May;151(1):56-70
pubmed: 28039862
Cell Death Dis. 2014 Feb 20;5:e1073
pubmed: 24556688
Transplant Proc. 2013 Jun;45(5):1853-5
pubmed: 23769057
Biochem Biophys Res Commun. 1998 Aug 19;249(2):505-11
pubmed: 9712726
Immunol Rev. 2008 Aug;224:166-82
pubmed: 18759926
Cell. 2003 Jun 13;113(6):685-700
pubmed: 12809600
Gastroenterology. 2006 Dec;131(6):1786-98
pubmed: 17087939
N Engl J Med. 2012 Jun 28;366(26):2443-54
pubmed: 22658127
Nucleic Acids Res. 2003 Jul 1;31(13):3651-3
pubmed: 12824386
Front Immunol. 2011 Jul 01;2:25
pubmed: 22566815
Bioinformatics. 2002 Feb;18(2):333-4
pubmed: 11847087
Nat Med. 2009 Jul;15(7):757-65
pubmed: 19584867
Cancer Discov. 2016 Dec;6(12):1366-1381
pubmed: 27683557
J Exp Med. 2008 Sep 1;205(9):2139-49
pubmed: 18710932
Immunol Rev. 2013 Mar;252(1):164-82
pubmed: 23405904
ACG Case Rep J. 2017 Oct 11;4:e112
pubmed: 29043290
J Immunol. 2009 Feb 15;182(4):2102-12
pubmed: 19201863
J Vis Exp. 2012 Feb 01;(60):null
pubmed: 22331082
J Am Soc Nephrol. 2014 Jan;25(1):105-18
pubmed: 24158981
Br J Cancer. 2008 Sep 16;99(6):957-65
pubmed: 18781153
Immunity. 2012 Aug 24;37(2):264-75
pubmed: 22902234
J Clin Invest. 2015 Mar 2;125(3):1069-80
pubmed: 25642768
Annu Rev Immunol. 2009;27:313-38
pubmed: 19302043
Nat Commun. 2017 Sep 20;8(1):620
pubmed: 28931816
Immunity. 2015 Jul 21;43(1):65-79
pubmed: 26141582
Cancers (Basel). 2019 May 01;11(5):null
pubmed: 31052449
Mucosal Immunol. 2016 Mar;9(2):336-51
pubmed: 26174764
FASEB J. 2000 Jun;14(9):1147-58
pubmed: 10834937
Arthritis Rheum. 2008 Jan;58(1):221-6
pubmed: 18163503
Inflamm Bowel Dis. 2017 Sep;23(9):1524-1534
pubmed: 28700533
Annu Rev Immunol. 2010;28:573-621
pubmed: 20192811
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E856-65
pubmed: 24550510
PLoS One. 2014 Jun 19;9(6):e100217
pubmed: 24945909
Cell Rep. 2014 Feb 27;6(4):625-32
pubmed: 24529703
Curr Opin Gastroenterol. 2008 Nov;24(6):733-41
pubmed: 19125486
Immunol Rev. 2010 Jul;236:219-42
pubmed: 20636820
Front Pharmacol. 2017 Oct 18;8:730
pubmed: 29093678
JCI Insight. 2018 Mar 8;3(5):
pubmed: 29515025
Sci Rep. 2016 May 26;6:26747
pubmed: 27226337
Cytokine Growth Factor Rev. 2003 Apr;14(2):85-9
pubmed: 12651220
Immunol Rev. 2011 May;241(1):206-27
pubmed: 21488899
J Clin Invest. 2014 Oct;124(10):4190-6
pubmed: 25083986
J Exp Med. 2003 Dec 15;198(12):1875-86
pubmed: 14676299
Immunity. 2016 Apr 19;44(4):924-38
pubmed: 27096321
Nat Immunol. 2007 Mar;8(3):239-45
pubmed: 17304234
J Exp Med. 2007 Aug 6;204(8):1757-64
pubmed: 17620361
J Gastrointest Oncol. 2018 Feb;9(1):160-169
pubmed: 29564182
Blood. 2009 Oct 8;114(15):3235-43
pubmed: 19625705
J Exp Med. 2009 Dec 21;206(13):3015-29
pubmed: 20008522
Sci Transl Med. 2016 Mar 2;8(328):328rv4
pubmed: 26936508
J Neuroimmunol. 2007 Jul;187(1-2):61-73
pubmed: 17553571
J Immunol. 2006 Feb 15;176(4):2238-48
pubmed: 16455980
Gastroenterology. 2005 Nov;129(5):1420-9
pubmed: 16285943
Gut. 2015 Feb;64(2):260-71
pubmed: 24902766
Gastroenterology. 2018 Jan;154(1):61-64.e6
pubmed: 28847751
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1480-E1489
pubmed: 28167776
J Clin Invest. 2001 Aug;108(4):601-9
pubmed: 11518734