Meta-analysis of Chromatin Programming by Steroid Receptors.
FOXA1
chromatin
chromatin remodelers
dynamic assisted loading
pioneer factors
steroid receptors
transcription factors
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
24 09 2019
24 09 2019
Historique:
received:
15
05
2019
revised:
08
08
2019
accepted:
12
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
ppublish
Résumé
Transcription factors (TFs) must access chromatin to bind to their response elements and regulate gene expression. A widely accepted model proposes that only a special subset of TFs, pioneer factors, can associate with condensed chromatin and initiate chromatin opening. We previously reported that steroid receptors (SRs), not considered pioneer factors, can assist the binding of an archetypal pioneer, the forkhead box protein 1 (FOXA1), at a subset of receptor-activated enhancers. These findings have been challenged recently, with the suggestion that newly acquired data fully support the prevailing pioneer model. Here, we reexamine our results and confirm the original conclusions. We also analyze and discuss a number of available datasets relevant to chromatin penetration by SRs and find a general consensus supporting our original observations. Hence, we propose that chromatin opening at some sites can be initiated by SRs, with a parallel recruitment of factors often treated as having a unique pioneer function. This Matters Arising paper is in response to Glont et al. (2019), published in Cell Reports.
Identifiants
pubmed: 31553919
pii: S2211-1247(19)31079-4
doi: 10.1016/j.celrep.2019.08.039
pmc: PMC6914262
mid: NIHMS1543787
pii:
doi:
Substances chimiques
Receptors, Steroid
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3523-3534.e2Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC005450-25
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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