Mid-cervical interneuron networks following high cervical spinal cord injury.
Cervical interneurons
Connectivity
Plasticity
Spinal cord injury
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
12
07
2019
revised:
22
08
2019
accepted:
20
09
2019
pubmed:
26
9
2019
medline:
6
6
2020
entrez:
26
9
2019
Statut:
ppublish
Résumé
Spinal interneuron (IN) networks can facilitate respiratory motor recovery after spinal cord injury (SCI). We hypothesized that excitatory synaptic connectivity between INs located immediately caudal to unilateral cervical SCI would be most prevalent in a contra- to ipsilateral direction. Adult rats were studied following chronic C2 spinal cord hemisection (C2Hx) injury. Rats were anesthetized and ventilated and a multi-electrode array was used to simultaneously record INs on both sides of the C4-5 spinal cord. The temporal firing relationship between IN pairs was evaluated using cross-correlation with directionality of synaptic connections inferred based on electrode location. During baseline recordings, the majority of detectable excitatory IN connections occurred in a contra- to- ipsilateral direction. However, acute respiratory stimulation with hypoxia abolished this directionality, while simultaneously increasing the detectable inhibitory connections within the ipsilateral cord. We conclude that propriospinal networks caudal to SCI can display a contralateral-to-ipsilateral directionality of synaptic connections and that these connections are modulated by acute exposure to hypoxia.
Identifiants
pubmed: 31553921
pii: S1569-9048(19)30247-2
doi: 10.1016/j.resp.2019.103305
pmc: PMC6864252
mid: NIHMS1054138
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
103305Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL143207
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139708
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD043730
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS095620
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL143207
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080180
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Références
Exp Neurol. 2008 May;211(1):97-106
pubmed: 18308305
Am J Respir Crit Care Med. 2014 Jan 1;189(1):57-65
pubmed: 24224903
J Neurotrauma. 2015 Jun 15;32(12):893-907
pubmed: 25625912
Exp Physiol. 2007 Jan;92(1):87-97
pubmed: 17138622
Neurology. 2014 Jan 14;82(2):104-13
pubmed: 24285617
Exp Brain Res. 1996 Nov;112(1):35-40
pubmed: 8951404
Respir Physiol Neurobiol. 2005 Jul 28;147(2-3):235-51
pubmed: 15871925
J Neurophysiol. 2015 Apr 1;113(7):2091-101
pubmed: 25552641
Indian J Dermatol. 2016 Jul-Aug;61(4):385-92
pubmed: 27512183
Exp Neurol. 2014 Jun;256:46-56
pubmed: 24681155
J Neurophysiol. 2017 Mar 1;117(3):1014-1029
pubmed: 27974450
Exp Brain Res. 1989;78(3):624-32
pubmed: 2612605
J Neurosci. 2018 Sep 26;38(39):8329-8344
pubmed: 30049887
Nat Neurosci. 2004 Mar;7(3):269-77
pubmed: 14966523
Biol Cybern. 1987;57(6):403-14
pubmed: 3435728
J Neurophysiol. 2015 Oct;114(4):2162-86
pubmed: 26203111
Neurorehabil Neural Repair. 2012 Feb;26(2):163-72
pubmed: 21821826
Brain Res. 1983 Dec 12;288(1-2):105-18
pubmed: 6661613
J Comp Neurol. 2008 Dec 10;511(5):692-709
pubmed: 18924146
Exp Neurol. 1991 Jan;111(1):135-9
pubmed: 1984430
Nature. 2018 Oct;562(7727):419-422
pubmed: 30305735
Exp Neurol. 2017 Jan;287(Pt 2):225-234
pubmed: 27456270
J Appl Physiol (1985). 2015 Dec 15;119(12):1455-65
pubmed: 25997947
Exp Neurol. 2018 Feb;300:201-211
pubmed: 29146456
Exp Neurol. 1993 Apr;120(2):233-44
pubmed: 7684001
Exp Neurol. 2017 Jan;287(Pt 2):144-152
pubmed: 27208699
Exp Neurol. 2015 Jan;263:314-24
pubmed: 25448009
Respir Physiol Neurobiol. 2019 Jul;265:24-31
pubmed: 30315961
J Appl Physiol (1985). 2004 Jun;96(6):2057-72
pubmed: 15133012
Brain Res. 1999 Jan 30;817(1-2):25-33
pubmed: 9889307
Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1069-76
pubmed: 14764434
J Neurosci. 2012 Mar 14;32(11):3591-600
pubmed: 22423083
Exp Neurol. 1992 Jun;116(3):219-28
pubmed: 1375167
J Neurosci Methods. 1979 Aug;1(2):107-32
pubmed: 161793
J Appl Physiol (1985). 2003 Feb;94(2):795-810
pubmed: 12531916
Neural Plast. 2017;2017:1932875
pubmed: 29138697
Exp Neurol. 2017 Jan;287(Pt 2):192-204
pubmed: 27456268
Nat Neurosci. 2004 Jan;7(1):48-55
pubmed: 14699417
J Physiol. 1996 Dec 15;497 ( Pt 3):803-12
pubmed: 9003565
Trends Neurosci. 2018 Sep;41(9):625-639
pubmed: 30017476
Brain Res. 1990 Nov 12;533(1):141-6
pubmed: 2085725
Biophys J. 1970 Sep;10(9):876-900
pubmed: 4322240
J Neurotrauma. 2017 Nov 1;34(21):3058-3065
pubmed: 28548606
Exp Neurol. 2014 Nov;261:440-50
pubmed: 25086272
Cell Rep. 2017 Oct 17;21(3):654-665
pubmed: 29045834
J Comp Neurol. 1988 Mar 1;269(1):47-57
pubmed: 3361003
J Neurophysiol. 2008 Oct;100(4):1749-69
pubmed: 18632881
Brain Res. 1985 Aug 12;340(2):341-54
pubmed: 4027655
J Appl Physiol (1985). 2000 Aug;89(2):563-72
pubmed: 10926639
Ann N Y Acad Sci. 2013 Mar;1279:143-53
pubmed: 23531012
Exp Neurol. 1998 Mar;150(1):143-52
pubmed: 9514833
J Physiol. 1985 Nov;368:63-87
pubmed: 4078753
Exp Neurol. 1997 Oct;147(2):299-310
pubmed: 9344555
J Neurophysiol. 1989 May;61(5):900-17
pubmed: 2723733
Respir Physiol Neurobiol. 2009 Nov 30;169(2):123-32
pubmed: 19698805
J Physiol. 1895 Apr 6;17(6):455-85
pubmed: 16992199
Exp Neurol. 2004 Jun;187(2):468-77
pubmed: 15144873
Respir Physiol Neurobiol. 2009 Nov 30;169(2):85-93
pubmed: 19539790
J Neurosci. 2017 Aug 30;37(35):8349-8362
pubmed: 28751456
Exp Brain Res. 1992;90(1):153-62
pubmed: 1521604
Exp Brain Res. 1996 Sep;111(2):178-86
pubmed: 8891649