Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD.
biochemical diagnostic
fibrosis
genetic diagnostic
non-invasive scoring methods
nonalcoholic fatty liver disease (NAFLD)
nonalcoholic steatohepatitis (NASH)
steatosis
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
24 09 2019
24 09 2019
Historique:
received:
31
07
2019
revised:
16
09
2019
accepted:
20
09
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
6
2
2020
Statut:
epublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. It represents a range of disorders, including simple steatosis, nonalcoholic steatohepatitis (NASH), and liver cirrhosis, and its prevalence continues to rise. In some cases, hepatocellular carcinoma (HCC) may develop. The develop;ment of non-invasive diagnostic and screening tools is needed, in order to reduce the frequency of liver biopsies. The most promising methods are those able to exclude advanced fibrosis and quantify steatosis. In this study, new perspective markers for inflammation, oxidative stress, apoptosis, and fibrogenesis; emerging scoring models for detecting hepatic steatosis and fibrosis; and new genetic, epigenetic, and multiomic studies are discussed. As isolated biochemical parameters are not specific or sensitive enough to predict the presence of NASH and fibrosis, there is a tendency to use various markers and combine them into mathematical algorithms. Several predictive models and scoring systems have been developed. Current data suggests that panels of markers (NAFLD fibrosis score, Fib-4 score, BARD score, and others) are useful diagnostic modalities to minimize the number of liver biopsies. The review unveils pathophysiological aspects related to new trends in current non-invasive biochemical, genetic, and scoring methods, and provides insight into their diagnostic accuracies and suitability in clinical practice.
Identifiants
pubmed: 31554274
pii: ijerph16193570
doi: 10.3390/ijerph16193570
pmc: PMC6801903
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Mol Med. 2019 May 2;25(1):16
pubmed: 31046673
Int J Inflam. 2019 May 8;2019:6273680
pubmed: 31205673
Curr Pharm Des. 2019;25(18):2051-2059
pubmed: 31298151
BMJ Open. 2018 Apr 5;8(4):e019974
pubmed: 29626047
J Magn Reson Imaging. 2017 Oct;46(4):1149-1158
pubmed: 28225568
Metabolism. 2018 Oct;87:1-12
pubmed: 29935236
Hepatology. 2005 Sep;42(3):665-74
pubmed: 16116632
Mol Metab. 2018 Jul;13:56-66
pubmed: 29753678
Nat Commun. 2019 Apr 11;10(1):1684
pubmed: 30975991
Gut. 2010 Sep;59(9):1265-9
pubmed: 20801772
Am J Gastroenterol. 2014 Mar;109(3):325-34
pubmed: 24445574
Hepatol Res. 2016 Aug;46(9):862-70
pubmed: 26763834
Metabolism. 2016 Aug;65(8):1136-50
pubmed: 26477269
Liver Int. 2008 Apr;28(4):519-24
pubmed: 17976158
Hepatology. 2017 Nov;66(5):1474-1485
pubmed: 28493388
Environ Int. 2019 Oct;131:104978
pubmed: 31325714
Bratisl Lek Listy. 2017;118(1):51-55
pubmed: 28127983
Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):135-9
pubmed: 21476906
PLoS One. 2016 Apr 14;11(4):e0153497
pubmed: 27077736
IUBMB Life. 2019 Sep;71(9):1382-1390
pubmed: 31087761
Redox Biol. 2018 May;15:467-479
pubmed: 29413959
Front Immunol. 2019 Jun 04;10:1255
pubmed: 31214196
PLoS Genet. 2011 Mar;7(3):e1001324
pubmed: 21423719
J Hepatol. 2012 Sep;57(3):541-8
pubmed: 22612998
Int J Mol Sci. 2017 Sep 12;18(9):null
pubmed: 28895919
Hepatology. 2011 Jun;53(6):1883-94
pubmed: 21381068
World J Gastroenterol. 2015 Oct 21;21(39):11088-111
pubmed: 26494964
Curr Environ Health Rep. 2019 Sep;6(3):95-104
pubmed: 31090041
Diabetes Metab Syndr Obes. 2019 Jan 24;12:181-190
pubmed: 30774403
Intern Med J. 2018 Nov;48(11):1369-1376
pubmed: 29845719
Curr Med Chem. 2012;19(28):4850-60
pubmed: 22709007
Expert Rev Mol Diagn. 2007 Sep;7(5):481-90
pubmed: 17892356
Invest Radiol. 2012 Jun;47(6):368-75
pubmed: 22543969
Atherosclerosis. 2019 Apr;283:137-142
pubmed: 30655019
BMC Med. 2019 Apr 30;17(1):85
pubmed: 31035998
J Hepatol. 2016 Sep;65(3):589-600
pubmed: 27212244
Int J Environ Res Public Health. 2019 May 06;16(9):
pubmed: 31064061
World J Gastroenterol. 2015 Mar 21;21(11):3223-31
pubmed: 25805928
Saudi J Gastroenterol. 2012 Sep-Oct;18(5):327-33
pubmed: 23006461
Hepatology. 2019 Oct;70(4):1457-1469
pubmed: 30924946
Dig Dis. 2019;37(1):69-76
pubmed: 30016799
PLoS One. 2018 Mar 22;13(3):e0193191
pubmed: 29565984
J Hepatol. 2014 Jul;61(1):75-81
pubmed: 24607626
BMC Gastroenterol. 2008 Nov 14;8:53
pubmed: 19014569
Liver Int. 2019 Sep;39(9):1742-1754
pubmed: 31169972
J Gastroenterol Hepatol. 2019 Aug;34(8):1390-1395
pubmed: 30600551
Atherosclerosis. 2007 Apr;191(2):235-40
pubmed: 16970951
Expert Rev Gastroenterol Hepatol. 2019 Jul;13(7):667-681
pubmed: 31104523
Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):404-11
pubmed: 19474722
Ann Hepatol. 2012 Jul-Aug;11(4):440-9
pubmed: 22700625
Arch Endocrinol Metab. 2017 May-Jun;61(3):276-281
pubmed: 28225987
Clin Epigenetics. 2019 Jul 18;11(1):104
pubmed: 31319896
Metabolism. 2017 Jul;72:57-65
pubmed: 28641784
Expert Rev Gastroenterol Hepatol. 2015 May;9(5):603-27
pubmed: 25694178
Curr Med Chem. 2012;19(32):5467-73
pubmed: 22876924
Clin Gastroenterol Hepatol. 2009 Oct;7(10):1104-12
pubmed: 19523535
Int J Environ Res Public Health. 2019 May 06;16(9):
pubmed: 31064107
Scand J Gastroenterol. 2019 Mar;54(3):328-334
pubmed: 30907181
Hepatology. 1999 Jun;29(6):1743-51
pubmed: 10347117
Biomed Res Int. 2014;2014:658913
pubmed: 25110685
Dig Dis Sci. 2007 Oct;52(10):2622-8
pubmed: 17429733
Adv Biomed Res. 2016 Feb 15;5:28
pubmed: 27014655
Aliment Pharmacol Ther. 2012 Dec;36(11-12):1057-66
pubmed: 23066946
World J Gastroenterol. 2014 Dec 28;20(48):18070-91
pubmed: 25561778
PLoS One. 2018 Jun 1;13(6):e0198327
pubmed: 29856820
Digestion. 2015;92(3):130-7
pubmed: 26329758
Int J Environ Res Public Health. 2019 Jun 21;16(12):
pubmed: 31234281
Dig Liver Dis. 2017 May;49(5):471-483
pubmed: 28215516
J Hepatol. 2019 Jan;70(1):133-141
pubmed: 30291868
Hepatology. 2002 Aug;36(2):514-5; author reply 515
pubmed: 12143070
Ann Hepatol. 2018 Jun 4;17(4):585-591
pubmed: 29893699
World J Gastroenterol. 2019 Mar 21;25(11):1307-1326
pubmed: 30918425
Liver Int. 2019 Aug;39(8):1521-1534
pubmed: 30972903
World J Hepatol. 2015 Jun 18;7(11):1450-9
pubmed: 26085906
Hepatol Int. 2013 Jun;7(2):592-9
pubmed: 26201792
Hepatology. 2015 Feb;61(2):506-14
pubmed: 25251399
Metabolism. 2019 Oct;99:81-89
pubmed: 31279739
Dis Markers. 2009;26(2):55-63
pubmed: 19407360
Liver Int. 2016 Nov;36(11):1688-1695
pubmed: 27064133
Arq Bras Cardiol. 2018 Jun;110(6):522-523
pubmed: 30226909
Hepatology. 2017 Jun;65(6):2122-2123
pubmed: 28085205
PLoS One. 2013;8(3):e58360
pubmed: 23555578
PLoS One. 2014 Mar 17;9(3):e91987
pubmed: 24637477
Metabolism. 2016 Aug;65(8):1038-48
pubmed: 26823198
Int J Environ Res Public Health. 2019 May 17;16(10):
pubmed: 31108859
Aliment Pharmacol Ther. 2015 Jun;41(12):1271-80
pubmed: 25873207
Eur J Endocrinol. 2009 Dec;161(6):861-70
pubmed: 19773372
PLoS One. 2019 Jul 10;14(7):e0217263
pubmed: 31291245
BMC Gastroenterol. 2006 Nov 10;6:34
pubmed: 17096854
Cytometry B Clin Cytom. 2019 Jun 7;:null
pubmed: 31173462
BMC Med. 2018 Aug 24;16(1):148
pubmed: 30139362
Int J Environ Res Public Health. 2019 May 23;16(10):
pubmed: 31126119
Clujul Med. 2016;89(1):24-31
pubmed: 27004022
J Hepatol. 2013 Oct;59(4):859-71
pubmed: 23751754
PLoS One. 2012;7(3):e30325
pubmed: 22431959
Dig Liver Dis. 2015 Mar;47(3):181-90
pubmed: 25739820
Hepatology. 2008 Feb;47(2):455-60
pubmed: 18038452
Arch Med Sci Atheroscler Dis. 2018 Dec 28;3:e179-e183
pubmed: 30775610
J Hepatol. 2018 Feb;68(2):335-352
pubmed: 29122390
BMC Gastroenterol. 2010 Jun 28;10:67
pubmed: 20584330
Hepatol Res. 2016 Oct;46(11):1074-1087
pubmed: 26785389
Clin Exp Hepatol. 2018 Mar;4(1):1-6
pubmed: 29594192
Postgrad Med J. 2019 Jun;95(1124):314-322
pubmed: 31085617
Obes Surg. 2008 Nov;18(11):1430-7
pubmed: 18500507
World J Gastroenterol. 2014 Jul 14;20(26):8377-92
pubmed: 25024596
BMJ Open Gastroenterol. 2018 Mar 20;5(1):e000198
pubmed: 29607054
Minerva Gastroenterol Dietol. 2014 Mar;60(1):5-13
pubmed: 24632764
PLoS One. 2014 Sep 12;9(9):e107584
pubmed: 25216184
Arq Bras Cardiol. 2018 Jun;110(6):514-521
pubmed: 30226908
Saudi Med J. 2019 Jun;40(6):531-540
pubmed: 31219486
Hepatology. 2015 Aug;62(2):658-9
pubmed: 25482317
Biol Trace Elem Res. 2019 Apr;188(2):326-333
pubmed: 30014284
Front Physiol. 2018 Mar 15;9:193
pubmed: 29662454
Curr Med Chem. 2011;18(5):725-32
pubmed: 21182485
Diabetes Metab Syndr. 2019 May - Jun;13(3):2226-2229
pubmed: 31235161
World J Hepatol. 2015 Oct 28;7(24):2497-502
pubmed: 26523202
Liver Int. 2019 Jul 22;:null
pubmed: 31332938
Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:2988-2991
pubmed: 29060526
BMJ Open. 2019 Jun 27;9(6):e024073
pubmed: 31248913
Nat Genet. 2014 Apr;46(4):352-6
pubmed: 24531328
PLoS One. 2015 Jul 01;10(7):e0127782
pubmed: 26131717
Dig Liver Dis. 2015 Dec;47(12):997-1006
pubmed: 26454786
World J Gastroenterol. 2014 Jun 21;20(23):7392-402
pubmed: 24966609
Nutrients. 2018 May 21;10(5):null
pubmed: 29883377
Hepatology. 2016 Feb;63(2):453-61
pubmed: 26560734
Int J Mol Sci. 2019 Jun 11;20(11):null
pubmed: 31212642
Atherosclerosis. 2018 Mar;270:154-159
pubmed: 29425961
Endocrine. 2016 Feb;51(2):211-21
pubmed: 26024975
Biomark Med. 2013 Oct;7(5):737-45
pubmed: 24044566
Ann Hepatol. 2019 May - Jun;18(3):445-449
pubmed: 31031166
World J Gastroenterol. 2014 Oct 14;20(38):13920-9
pubmed: 25320528
BMC Gastroenterol. 2012 Jan 05;12:2
pubmed: 22221544
Clin Gastroenterol Hepatol. 2019 Aug;17(9):1877-1885.e5
pubmed: 30616027
Adv Exp Med Biol. 2018;1061:19-44
pubmed: 29956204
Nat Genet. 2008 Dec;40(12):1461-5
pubmed: 18820647
Gastroenterology. 2001 Jul;121(1):91-100
pubmed: 11438497
World J Gastroenterol. 2017 Sep 28;23(36):6571-6592
pubmed: 29085206
Gastroenterology. 2019 Apr;156(5):1264-1281.e4
pubmed: 30660725
Medicine (Baltimore). 2015 Oct;94(40):e1682
pubmed: 26448014
Obes Surg. 2019 Aug;29(8):2562-2570
pubmed: 31016455
PLoS One. 2014 Oct 28;9(10):e111551
pubmed: 25350286
J Hepatol. 2019 Aug;71(2):389-396
pubmed: 31102719
Radiology. 2010 Aug;256(2):640-7
pubmed: 20529989
Gastroenterol Clin Biol. 2008 Sep;32(6 Suppl 1):40-51
pubmed: 18973845
Int J Mol Sci. 2019 Apr 20;20(8):
pubmed: 31010049
Clin Diabetes. 2019 Jan;37(1):65-72
pubmed: 30705499
J Gastroenterol Hepatol. 2016 May;31(5):936-44
pubmed: 26667191
Dig Liver Dis. 2010 Jul;42(7):503-8
pubmed: 19766548
Eur J Endocrinol. 2014 Nov;171(5):561-9
pubmed: 25298375
Gastroenterol Hepatol. 2014 Nov;37(9):503-10
pubmed: 24746708
Hepatology. 2018 Jan;67(1):134-144
pubmed: 28859228
World J Hepatol. 2014 Jul 27;6(7):496-503
pubmed: 25068001
Aliment Pharmacol Ther. 2011 Aug;34(3):274-85
pubmed: 21623852
Atherosclerosis. 2019 May;284:59-65
pubmed: 30875494
World J Gastroenterol. 2018 May 21;24(19):2073-2082
pubmed: 29785076
Diabetes. 2018 Aug;67(8):1604-1615
pubmed: 29802129
Sci Rep. 2015 Nov 16;5:16494
pubmed: 26568423
BMC Gastroenterol. 2019 Apr 8;19(1):51
pubmed: 30961539
Expert Rev Gastroenterol Hepatol. 2019 Jun;13(6):523-530
pubmed: 31018719
N Engl J Med. 2019 Feb 14;380(7):681-683
pubmed: 30763194
Int J Cardiol. 2018 Dec 1;272:316-322
pubmed: 30072152
Hepatology. 2007 Apr;45(4):846-54
pubmed: 17393509
J Diabetes Investig. 2013 Nov 27;4(6):651-8
pubmed: 24843721
Eur J Gastroenterol Hepatol. 2009 May;21(5):504-11
pubmed: 19318968
Ann Hepatol. 2013 May-Jun;12(3):416-24
pubmed: 23619258
Acta Diabetol. 2019 Apr;56(4):385-396
pubmed: 30519965
Ter Arkh. 2019 May 16;91(4):21-27
pubmed: 31094472
Hepatology. 2004 Jun;39(6):1748; author reply 1749
pubmed: 15185321
Atherosclerosis. 2018 Aug;275:50-57
pubmed: 29860108
World J Gastroenterol. 2014 Oct 21;20(39):14185-204
pubmed: 25339806
World J Gastroenterol. 2015 Apr 21;21(15):4432-9
pubmed: 25914452
Gastroenterology. 2000 Jun;118(6):1117-23
pubmed: 10833486
Hepatol Int. 2019 May;13(3):323-329
pubmed: 30993598
World J Gastroenterol. 2014 Jun 21;20(23):7089-103
pubmed: 24966582
Curr Opin Gastroenterol. 2018 Jul;34(4):272-279
pubmed: 29697467
Liver Int. 2006 Mar;26(2):151-6
pubmed: 16448452
Dig Liver Dis. 2018 Apr;50(4):370-377
pubmed: 29398414
Clin Gastroenterol Hepatol. 2012 Oct;10(10):1162-8; quiz e87
pubmed: 22796457
J Magn Reson Imaging. 2013 Mar;37(3):544-55
pubmed: 23423795
Obesity (Silver Spring). 2013 Sep;21(9):1935-41
pubmed: 23418085
Ont Health Technol Assess Ser. 2015 Nov 01;15(18):1-45
pubmed: 26664664
Biomed Res Int. 2016;2016:5170402
pubmed: 27822476
J Clin Exp Hepatol. 2012 Jun;2(2):145-55
pubmed: 25755423
J Clin Lipidol. 2018 Jul - Aug;12(4):981-987
pubmed: 29699915
S Afr Med J. 2011 Jun 27;101(7):477-80
pubmed: 21920102
J Hepatol. 2006 Jan;44(1):190-6
pubmed: 16168516
Hepatology. 2006 Jun;43(6):1317-25
pubmed: 16729309
Eur J Gastroenterol Hepatol. 2018 Sep;30(9):979-985
pubmed: 30048367
Hepatology. 2011 Sep 2;54(3):1082-1090
pubmed: 21618575
Hepatology. 2016 Mar;63(3):827-38
pubmed: 26599351
Hepatology. 2010 Jan;51(1):111-20
pubmed: 19885878
Metabolites. 2019 Jun 24;9(6):null
pubmed: 31238601
Scand J Clin Lab Invest. 2017 May;77(3):205-209
pubmed: 28318371
Croat Med J. 2015 Oct;56(5):470-81
pubmed: 26526884