Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study.
IL-1α
animal model
inflammation
subarachnoid hemorrhage
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
24 Sep 2019
24 Sep 2019
Historique:
received:
06
08
2019
revised:
20
09
2019
accepted:
23
09
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
27
9
2019
Statut:
epublish
Résumé
The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods There was a significant increase of ICP ( Systemic IL-1α levels are elevated after SAH induction in a rabbit SAH model.
Sections du résumé
BACKGROUND
BACKGROUND
The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods
RESULTS
RESULTS
There was a significant increase of ICP (
CONCLUSIONS
CONCLUSIONS
Systemic IL-1α levels are elevated after SAH induction in a rabbit SAH model.
Identifiants
pubmed: 31554320
pii: brainsci9100249
doi: 10.3390/brainsci9100249
pmc: PMC6827074
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors have no financial or other conflict of interest to declare.
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