In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer.
Acacia nilotica
Colon cancer
Helicobacter pylori
Pyrogallol
Toxicity
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
18
12
2018
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
27
2
2020
Statut:
epublish
Résumé
Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines
for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance of
practicing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported
an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells in
vitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract
of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed and
In vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated
different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar to
doxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion:
Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.
Identifiants
pubmed: 31554359
doi: 10.31557/APJCP.2019.20.9.2645
pmc: PMC6976835
pii:
doi:
Substances chimiques
Antioxidants
0
Plant Extracts
0
Pyrogallol
01Y4A2QXY0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2645-2651Références
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