Renal glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents.
Adolescent
Age Factors
Blood Pressure
Body Mass Index
Body Weight
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Glycosuria, Renal
/ diagnosis
Health Surveys
Humans
Hypertension
/ diagnosis
Israel
/ epidemiology
Male
Military Personnel
Mutation
Pediatric Obesity
/ diagnosis
Phenotype
Prevalence
Risk Assessment
Risk Factors
Sex Factors
Sodium-Glucose Transporter 2
/ genetics
Blood pressure
Glucosuria
Obesity
Overweight
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
25 09 2019
25 09 2019
Historique:
received:
08
07
2019
accepted:
17
09
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
12
5
2020
Statut:
epublish
Résumé
Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force's conscription center's database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal glucosuria was conducted. In addition, we assessed the association of renal glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used. The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50-0.87) and 0.62 (95% CI 0.43-0.88), respectively. Adolescents afflicted with renal glucosuria were also less likely to have an elevated systolic blood pressure of 130-139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60-0.90). Renal glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
Sections du résumé
BACKGROUND
Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal glucosuria is associated with lower body weight and lower blood pressure values.
METHODS
Medical and socio-demographic data were collected from the Israeli Defense Force's conscription center's database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal glucosuria was conducted. In addition, we assessed the association of renal glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used.
RESULTS
The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50-0.87) and 0.62 (95% CI 0.43-0.88), respectively. Adolescents afflicted with renal glucosuria were also less likely to have an elevated systolic blood pressure of 130-139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60-0.90).
CONCLUSIONS
Renal glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
Identifiants
pubmed: 31554505
doi: 10.1186/s12933-019-0929-7
pii: 10.1186/s12933-019-0929-7
pmc: PMC6760097
doi:
Substances chimiques
SLC5A2 protein, human
0
Sodium-Glucose Transporter 2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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