Differential Effect of Mucosal NKp44
Animals
Antibody-Dependent Cell Cytotoxicity
Female
Immunity, Innate
Immunity, Mucosal
Killer Cells, Natural
/ immunology
Lymphocyte Subsets
/ immunology
Macaca mulatta
Natural Cytotoxicity Triggering Receptor 2
/ analysis
Rectum
/ immunology
SAIDS Vaccines
/ immunology
Simian Acquired Immunodeficiency Syndrome
/ immunology
Vaccination
Vagina
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
17
05
2019
accepted:
29
08
2019
pubmed:
27
9
2019
medline:
29
5
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
NK cells are essential for controlling viral infections. We investigated NK cell and innate lymphoid cell (ILC) dynamics and function in rhesus macaque rectal tissue and blood following mucosal priming with replicating adenovirus (Ad)-SIV recombinants, systemic boosting with SIV envelope protein, and subsequent repeated low-dose intravaginal SIV exposures. Mucosal memory-like NK and ILC subsets in rectal and vaginal tissues of chronically infected macaques were also evaluated. No differences in NK cell or ILC frequencies or cytokine production were seen between vaccinated and Ad-empty/alum controls, suggesting responses were due to the Ad-vector and alum vaccine components. Mucosal NKp44
Identifiants
pubmed: 31554692
pii: jimmunol.1900572
doi: 10.4049/jimmunol.1900572
pmc: PMC6810926
mid: NIHMS1538966
doi:
Substances chimiques
NCR2 protein, human
0
Natural Cytotoxicity Triggering Receptor 2
0
SAIDS Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2459-2471Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC011062-01
Pays : United States
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