Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD.
TNFR1
biomarkers
cognitive decline
cytokines
inflammation
preclinical AD
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
05
2019
accepted:
12
08
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
27
9
2019
Statut:
epublish
Résumé
To examine the prospective association between blood biomarkers of immune functioning (i.e., innate immune activation, adaptive immunity, and inflammation) and subsequent cognitive decline and clinical progression to mild cognitive impairment (MCI) in cognitively normal individuals. The BIOCARD study is an observational cohort study of Higher levels of plasma TNFR1 were associated with greater risk of progression from normal cognition to MCI (HR: 3.27; 95% confidence interval, CI: 1.27, 8.40). Elevated levels of TNFR1 were also associated with steeper rate of cognitive decline on follow-up but not with baseline cognitive performance. Baseline IL-6 levels and markers of innate and adaptive immune activation showed no relationship with MCI risk or cognitive decline. Inflammation, mediated by TNF signaling, may play a selective role in the early phase of AD. Accordingly, plasma TNFR1 may facilitate improved prediction of disease progression for individuals in the preclinical stage of AD.
Identifiants
pubmed: 31555121
doi: 10.3389/fnagi.2019.00229
pmc: PMC6742958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
229Subventions
Organisme : NIA NIH HHS
ID : P30 AG021334
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG033655
Pays : United States
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