Cytotoxic effects of
Apoptosis
Cytotoxicity
HPLC fractions
Persian horned viper
Pseudocerastes persicus venom
Journal
The journal of venomous animals and toxins including tropical diseases
ISSN: 1678-9199
Titre abrégé: J Venom Anim Toxins Incl Trop Dis
Pays: Brazil
ID NLM: 101201501
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
02
2019
accepted:
06
08
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
27
9
2019
Statut:
epublish
Résumé
Several studies have pointed out that certain snake venoms contain compounds presenting cytotoxic activities that selectively interfere with cancer cell metabolism. In this study, Lung cancer cells (A549) and normal fibroblast cells (Hu02) were treated with the The treatment of cells with HPLC fraction 21 (25-35 kDa) of HPLC fraction 21 at low concentrations displayed promising anticancer properties with apoptosis induction in the lung cancer cells. This fraction may, therefore, be considered a promising candidate for further studies.
Sections du résumé
BACKGROUND
BACKGROUND
Several studies have pointed out that certain snake venoms contain compounds presenting cytotoxic activities that selectively interfere with cancer cell metabolism. In this study,
METHODS
METHODS
Lung cancer cells (A549) and normal fibroblast cells (Hu02) were treated with the
RESULTS
RESULTS
The treatment of cells with HPLC fraction 21 (25-35 kDa) of
CONCLUSION
CONCLUSIONS
HPLC fraction 21 at low concentrations displayed promising anticancer properties with apoptosis induction in the lung cancer cells. This fraction may, therefore, be considered a promising candidate for further studies.
Identifiants
pubmed: 31555336
doi: 10.1590/1678-9199-JVATITD-2019-0009
pmc: PMC6748451
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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