Decoding communication patterns of the innate immune system by quantitative proteomics.
activation
cellular mapping
drug discovery
innate immunity
leukocytes
mass spectrometry-based proteomics
phagocytic cells
signaling cascades
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
08
2019
revised:
12
09
2019
accepted:
13
09
2019
pubmed:
27
9
2019
medline:
4
6
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
The innate immune system is a collective network of cell types involved in cell recruitment and activation using a robust and refined communication system. Engagement of receptor-mediated intracellular signaling initiates communication cascades by conveying information about the host cell status to surrounding cells for surveillance and protection. Comprehensive profiling of innate immune cells is challenging due to low cell numbers, high dynamic range of the cellular proteome, low abundance of secreted proteins, and the release of degradative enzymes (e.g., proteases). However, recent advances in mass spectrometry-based proteomics provides the capability to overcome these limitations through profiling the dynamics of cellular processes, signaling cascades, post-translational modifications, and interaction networks. Moreover, integration of technologies and molecular datasets provide a holistic view of a complex and intricate network of communications underscoring host defense and tissue homeostasis mechanisms. In this Review, we explore the diverse applications of mass spectrometry-based proteomics in innate immunity to define communication patterns of the innate immune cells during health and disease. We also provide a technical overview of mass spectrometry-based proteomic workflows, with a focus on bottom-up approaches, and we present the emerging role of proteomics in immune-based drug discovery while providing a perspective on new applications in the future.
Identifiants
pubmed: 31556465
doi: 10.1002/JLB.2RI0919-302R
pmc: PMC7309189
mid: NIHMS1599255
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1221-1232Subventions
Organisme : NEI NIH HHS
ID : R01 EY022054
Pays : United States
Informations de copyright
©2019 Society for Leukocyte Biology.
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