Adenocarcinoma
/ drug therapy
Antineoplastic Agents
/ pharmacology
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Biological Products
/ pharmacology
Cell Death
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Chromatography, Liquid
/ methods
DNA Damage
/ drug effects
Flavonoids
/ pharmacology
Honey
Humans
Phenols
/ pharmacology
Quercus
/ chemistry
Reactive Oxygen Species
/ metabolism
Stomach Neoplasms
/ drug therapy
Tandem Mass Spectrometry
/ methods
DNA damage
Quercus pyrenaica
apitherapy
apoptosis
gastric carcinoma
honey
reactive oxygen species
Journal
Integrative cancer therapies
ISSN: 1552-695X
Titre abrégé: Integr Cancer Ther
Pays: United States
ID NLM: 101128834
Informations de publication
Date de publication:
Historique:
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
5
3
2020
Statut:
ppublish
Résumé
Many studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains
Identifiants
pubmed: 31556752
doi: 10.1177/1534735419876334
pmc: PMC6764044
doi:
Substances chimiques
Antineoplastic Agents
0
Antioxidants
0
Biological Products
0
Flavonoids
0
Phenols
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1534735419876334Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Type : CommentIn
Références
BMC Complement Altern Med. 2010 Sep 14;10:49
pubmed: 20840769
Oncogene. 2011 Jan 20;30(3):253-64
pubmed: 20972457
FEBS Lett. 2005 Jun 6;579(14):3131-5
pubmed: 15919081
Plant Foods Hum Nutr. 2017 Dec;72(4):388-395
pubmed: 28929426
Methods. 2009 May;48(1):46-53
pubmed: 19269328
Food Funct. 2018 Apr 25;9(4):2145-2157
pubmed: 29645049
Nutr Metab (Lond). 2011 Oct 26;8:75
pubmed: 22029671
PLoS One. 2013;8(2):e55993
pubmed: 23409104
Clin Exp Pharmacol Physiol. 2015 Aug;42(8):843-8
pubmed: 26041312
BMC Biotechnol. 2005 May 10;5:12
pubmed: 15885144
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Curr Opin Cell Biol. 1995 Jun;7(3):337-43
pubmed: 7662363
Clin Biochem. 2004 Apr;37(4):277-85
pubmed: 15003729
Cell Physiol Biochem. 2001;11(4):173-86
pubmed: 11509825
Food Chem Toxicol. 2011 Apr;49(4):871-8
pubmed: 21167897
Integr Cancer Ther. 2012 Dec;11(4):354-63
pubmed: 21147814
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011;29(1):1-31
pubmed: 21424974
Ann N Y Acad Sci. 2005 Nov;1056:218-33
pubmed: 16387690
Oncotarget. 2016 Aug 9;7(32):52517-52529
pubmed: 27232756
Anticancer Agents Med Chem. 2015;15(1):48-56
pubmed: 25052987
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
Exp Cell Res. 1988 Mar;175(1):184-91
pubmed: 3345800
Methods Cell Biol. 1995;46:153-85
pubmed: 7541883
Carcinogenesis. 2007 Feb;28(2):233-9
pubmed: 17151090
Asian Pac J Cancer Prev. 2014;15(11):4651-7
pubmed: 24969899
Food Chem Toxicol. 2008 Dec;46(12):3774-9
pubmed: 18940227
Free Radic Biol Med. 2018 Oct;126:41-54
pubmed: 30056083
J Am Coll Nutr. 2008 Dec;27(6):677-89
pubmed: 19155427
Crit Rev Food Sci Nutr. 2018;58(17):2908-2924
pubmed: 28682647
Int J Mol Sci. 2017 Mar 11;18(3):
pubmed: 28287469
Cell Mol Biol (Noisy-le-grand). 2017 Nov 30;63(11):97-105
pubmed: 29208180
Asian Pac J Cancer Prev. 2012;13(4):1605-10
pubmed: 22799375
BMC Complement Altern Med. 2011 Sep 26;11:82
pubmed: 21943200