Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study.
Adult
Aged
Biopsy
Candida
/ isolation & purification
Candidiasis, Oral
/ diagnosis
Female
Fluorescence
Humans
Male
Middle Aged
Molecular Imaging
/ methods
Optical Imaging
/ methods
Porphyrins
/ chemistry
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Tongue
/ diagnostic imaging
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
05
2019
accepted:
12
09
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
13
3
2020
Statut:
epublish
Résumé
To investigate the correlation between the dorsal tongue porphyrin autofluorescence, revealed using VELscope, and Candida saprophytism. Consecutive patients underwent an autofluorescence examination by the VELscope device to establish the presence or absence of porphyrin fluorescence. A tongue swab was collected for the Candida cultural test. Sensitivity, specificity, accuracy, negative predictive value and positive predictive value were calculated considering the oral swab as the gold standard. The degree of agreement between the two tests was calculated using Cohen's K coefficient. One hundred twenty-six patients were enrolled. Porphyrin fluorescence method showed a sensitivity of 78%, specificity of 76% and an accuracy of 78%. Negative predictive value and positive predictive value were respectively 90% and 59%. The strength of agreement between the two methods resulted to be moderate (k = 0.551). Off-label use of tongue autofluorescence examination to detect the presence of Candida species is characterized by a loss of porphyrin fluorescence. The high negative predictive value of porphyrin fluorescence loss suggests its use in preliminary selection of Candida carriers, in order to plan preventive and therapeutic strategies.
Identifiants
pubmed: 31557235
doi: 10.1371/journal.pone.0223072
pii: PONE-D-19-14725
pmc: PMC6762088
doi:
Substances chimiques
Porphyrins
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0223072Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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