A new photosafety screening strategy based on in chemico photoreactivity and in vitro skin exposure for dermally-applied chemicals.
In vitro skin permeation test
Photosafety assessment
Phototoxicity
Reactive oxygen species
Skin exposure
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
15 Dec 2019
15 Dec 2019
Historique:
received:
15
05
2019
revised:
09
09
2019
accepted:
20
09
2019
pubmed:
27
9
2019
medline:
20
11
2019
entrez:
27
9
2019
Statut:
ppublish
Résumé
This study involved an attempt to establish a new photosafety screening system for dermally-applied chemicals consisting of a reactive oxygen species (ROS) assay and an in vitro skin permeation test. The ROS assay was undertaken to evaluate photoreactivity of six test compounds, acridine (ACD), furosemide (FSM), hexachlorophene (HCP), 8-methoxypsoralen (MOP), norfloxacin (NFX), and promethazine (PMZ), and the in vitro skin permeation test was conducted to obtain steady-state concentration (C
Identifiants
pubmed: 31557510
pii: S0378-4274(19)30287-5
doi: 10.1016/j.toxlet.2019.09.016
pii:
doi:
Substances chimiques
Acridines
0
Reactive Oxygen Species
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-52Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.