Bacterial peptidoglycans as novel signaling molecules from microbiota to brain.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
20
08
2019
revised:
21
08
2019
accepted:
28
08
2019
pubmed:
27
9
2019
medline:
25
8
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
Mounting evidence indicates that gut microbiota exerts a broad range of effects on host physiology and development beyond the gastrointestinal tract, including the modulation of brain development. However, the mechanisms mediating the interactions between the microbiota and the developing brain are still poorly understood. Pattern recognition receptors of the innate immune system that recognize microbial products, such as peptidoglycans have emerged as potential key regulators of gut microbiome-brain interactions. Peptidoglycan-sensing molecules are expressed in the placenta and brain during specific time windows of development. Moreover, peptidoglycans are ubiquitously present in circulation and can cross the blood brain barrier. This review brings together the current evidence supporting a broad function of peptidoglycans well beyond host's immunity, extending to neurodevelopment and behavior.
Identifiants
pubmed: 31557694
pii: S1471-4892(19)30085-2
doi: 10.1016/j.coph.2019.08.003
pii:
doi:
Substances chimiques
Peptidoglycan
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-113Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.