Circulating glucuronic acid predicts healthspan and longevity in humans and mice.
aging
glucuronate
glucuronic acid
lifespan
mortality
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
26 09 2019
26 09 2019
Historique:
received:
07
08
2019
accepted:
07
09
2019
pubmed:
27
9
2019
medline:
9
9
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10
Identifiants
pubmed: 31557729
doi: 10.18632/aging.102281
pii: 102281
pmc: PMC6781977
doi:
Substances chimiques
Biomarkers
0
Glucuronic Acid
8A5D83Q4RW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7694-7706Subventions
Organisme : British Heart Foundation
ID : SP/14/8/31352
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M016560/1
Pays : United Kingdom
Références
Elife. 2017 Nov 17;6:
pubmed: 29148970
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
J Lab Clin Med. 1956 Apr;47(4):583-91
pubmed: 13307093
Am J Epidemiol. 1979 Sep;110(3):281-90
pubmed: 474565
Mutat Res. 2001 Sep 1;480-481:129-38
pubmed: 11506806
Int J Epidemiol. 2015 Aug;44(4):1137-47
pubmed: 24518929
J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):232-46
pubmed: 24846769
Lancet. 2016 Mar 5;387(10022):957-967
pubmed: 26724178
Biochem Cell Biol. 2008 Jun;86(3):235-43
pubmed: 18523484
Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1667-9
pubmed: 1394691
Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):358-9
pubmed: 16819479
Brain Behav Immun. 2013 May;30:24-32
pubmed: 23348028
Trans Assoc Am Physicians. 1965;78:158-73
pubmed: 5864969
Rejuvenation Res. 2013 Oct;16(5):352-63
pubmed: 23777470
Plant Foods Hum Nutr. 2001;56(1):13-21
pubmed: 11213165
Carcinogenesis. 2007 Nov;28(11):2419-25
pubmed: 17660508
Int J Epidemiol. 2013 Aug;42(4):1111-9
pubmed: 23838602
Nat Genet. 2017 Apr;49(4):568-578
pubmed: 28263315
J Cell Sci. 2013 May 1;126(Pt 9):1905-12
pubmed: 23720375
Biol Pharm Bull. 1994 Mar;17(3):423-6
pubmed: 8019510
Acta Physiol Scand. 1954 Jul 18;31(2-3):263-7
pubmed: 13197096
Arch Intern Med. 2011 Jun 27;171(12):1061-8
pubmed: 21321288
Pharmacol Ther. 2012 May;134(2):200-18
pubmed: 22322248
Drug Metab Pharmacokinet. 2018 Feb;33(1):9-16
pubmed: 29079228
Chem Biol. 2015 Sep 17;22(9):1238-49
pubmed: 26364932
Lancet. 1994 Jan 1;343(8888):35-8
pubmed: 7905049
FEMS Microbiol Ecol. 2008 Dec;66(3):487-95
pubmed: 18537837
Oncogene. 2008 Oct 27;27(50):6434-51
pubmed: 18955971
J Intern Med. 2017 Feb;281(2):106-122
pubmed: 27597529
Biochim Biophys Acta. 1962 Aug 27;62:574-5
pubmed: 13901448
Am J Epidemiol. 1987 Dec;126(6):1093-102
pubmed: 2825519
Pharmacol Ther. 1991;51(3):347-69
pubmed: 1792239
Kidney Int. 2012 Feb;81(3):300-6
pubmed: 22012132
J Clin Immunol. 2009 Jul;29(4):406-15
pubmed: 19459036
J Clin Invest. 1953 Aug;32(8):711-9
pubmed: 13069619
Metabolism. 1954 Jan;3(1):11-5
pubmed: 13119362
J Clin Invest. 2006 Aug;116(8):2280-2289
pubmed: 16841097
Transl Res. 2018 May;195:25-47
pubmed: 29291380
Drug Metab Dispos. 2004 Mar;32(3):281-90
pubmed: 14977861
Nat Commun. 2014 Dec 23;5:5759
pubmed: 25536025
Acta Chem Scand. 1972;26(9):3515-23
pubmed: 4631802
Beitr Pathol. 1972;147(1):6-20
pubmed: 5078912
Lancet. 2005 Oct 8;366(9493):1267-78
pubmed: 16214597
Cancer Med. 2014 Oct;3(5):1136-45
pubmed: 25044252
Gene Ther. 2000 Feb;7(3):224-31
pubmed: 10694799
Clin Pharmacokinet. 2002;41(10):751-90
pubmed: 12162761
J Natl Cancer Inst Monogr. 2000;(27):113-24
pubmed: 10963623
J Clin Invest. 1951 Jul;30(7):685-96
pubmed: 14850547
Clin Chim Acta. 2005 Nov;361(1-2):20-9
pubmed: 16004980
Methods Enzymol. 2005;400:263-72
pubmed: 16399354
Ann N Y Acad Sci. 1951 Dec;54(4):548-57
pubmed: 14903798
Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E597-606
pubmed: 22739104
Science. 1974 Feb 1;183(4123):416-7
pubmed: 4808971
Oncogene. 2004 Apr 12;23(16):2881-90
pubmed: 15077151
Int J Biochem Cell Biol. 2013 Jun;45(6):1121-32
pubmed: 23500526
Biol Chem. 2016 Dec 21;398(3):289-301
pubmed: 28002019
Matrix Biol. 2019 Jan;75-76:286-299
pubmed: 29337052
Dig Dis Sci. 1988 Jan;33(1):41-6
pubmed: 3123178
Nature. 2012 Aug 9;488(7410):178-84
pubmed: 22797518
Carcinogenesis. 1998 Oct;19(10):1815-9
pubmed: 9806164
J Clin Invest. 2014 Oct;124(10):4173-81
pubmed: 25105361
Gut Microbes. 2017 Mar 4;8(2):172-184
pubmed: 28165863
J Tissue Eng. 2014 Dec 20;5:2041731414557112
pubmed: 25610589
Biomaterials. 2002 Jan;23(2):481-9
pubmed: 11761169
Aging (Albany NY). 2017 Aug 31;9(8):1916-1925
pubmed: 28858850
J Med Microbiol. 1971 Nov;4(4):451-9
pubmed: 5002686
Front Aging Neurosci. 2014 Jun 16;6:127
pubmed: 24982633
J Am Soc Nephrol. 2014 Apr;25(4):657-70
pubmed: 24231662
Cell Metab. 2013 Jul 2;18(1):130-43
pubmed: 23823483
Metabolomics. 2017 Nov 8;13(12):155
pubmed: 31375927
Drug Discov Today. 2011 May;16(9-10):443-9
pubmed: 21262380
N Engl J Med. 2006 Jan 19;354(3):270-82
pubmed: 16421368
Arch Toxicol. 2003 Oct;77(10):561-7
pubmed: 14574443
Annu Rev Microbiol. 1986;40:367-93
pubmed: 3535648
Pol J Microbiol. 2010;59(4):265-9
pubmed: 21466044
Am J Clin Nutr. 2017 Mar;105(3):547-554
pubmed: 28077380
Drug Metab Dispos. 2005 Oct;33(10):1513-20
pubmed: 16033946
Biochem Biophys Res Commun. 2016 Oct 14;479(2):331-337
pubmed: 27641666
Hepatology. 2013 Feb;57(2):601-9
pubmed: 23055155
Kidney Int. 1980 Nov;18(5):636-47
pubmed: 7463957
Nat Commun. 2017 Oct 10;8(1):845
pubmed: 29018189
PLoS One. 2010 Feb 05;5(2):e9085
pubmed: 20140211
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
Biomed Pharmacother. 2003 Jul-Aug;57(5-6):195-202
pubmed: 12888254
PLoS One. 2016 Apr 04;11(4):e0152678
pubmed: 27042829
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4539-46
pubmed: 20615998
Br J Dermatol. 2004 Mar;150(3):401-13
pubmed: 15030321