Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status.
Aged
Aged, 80 and over
Alzheimer Disease
/ drug therapy
Amyloid
/ metabolism
Cognition
/ drug effects
Dietary Supplements
Fatty Acids, Omega-3
/ administration & dosage
Female
Humans
Longitudinal Studies
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
/ statistics & numerical data
Positron-Emission Tomography
Alzheimer
Amyloid
MAPT
Multidomain intervention
Omega-3
PET
Prevention
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
10
2018
revised:
02
07
2019
accepted:
14
07
2019
pubmed:
29
9
2019
medline:
1
9
2020
entrez:
28
9
2019
Statut:
ppublish
Résumé
The Multidomain Alzheimer Preventive Trial (MAPT) assessed the efficacy of omega-3 fatty acid supplementation, a multidomain intervention (MI), or a combination of both on cognition. Impact according to cerebral amyloid status was evaluated by PET scan. Participants were nondemented and had memory complaints, limitation in one instrumental activity of daily living, or slow gait. The primary outcome was a change from baseline in 36 months measured with a cognitive composite Z score. No effect was observed on cognition in the negative amyloid group (n = 167). In the positive amyloid group (n = 102), we observed a difference of 0.708 and 0.471 in the cognitive composite score between the MI plus omega-3 fatty acid group, the MI alone group, and the placebo group, respectively. MI alone or in combination with omega-3 fatty acids was associated with improved primary cognitive outcome in subjects with positive amyloid status. ClinicalTrials.gov Identifier: NCT01513252.
Identifiants
pubmed: 31558366
pii: S1552-5260(19)35131-3
doi: 10.1016/j.jalz.2019.07.008
pii:
doi:
Substances chimiques
Amyloid
0
Fatty Acids, Omega-3
0
Banques de données
ClinicalTrials.gov
['NCT01513252']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1392-1401Subventions
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH098062
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101472
Pays : United States
Informations de copyright
Copyright © 2019 the Alzheimer's Association. All rights reserved.