Hepatic senescence, the good and the bad.
Cell cycle arrest
Cholangiocyte
DNA damage
Hepatic stellate cell
Hepatocyte
Senescence
Senescence associated secretory phenotype
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Sep 2019
14 Sep 2019
Historique:
received:
26
06
2019
revised:
25
07
2019
accepted:
07
08
2019
entrez:
28
9
2019
pubmed:
29
9
2019
medline:
27
2
2020
Statut:
ppublish
Résumé
Gradual alterations of cell's physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent cells. Once becoming senescent, the cell stops dividing permanently but remains metabolically active. Cellular senescence does not have a single marker but is characterized mainly by a combination of multiple markers, such as, morphological changes, expression of cell cycle inhibitors, senescence associated β-galactosidase activity, and changes in nuclear membrane. When cells in an organ become senescent, the entire organism can be affected. This may occur through the senescence-associated secretory phenotype (SASP). SASP may exert beneficial or harmful effects on the microenvironment of tissues. Research on senescence has become a very exciting field in cell biology since the link between age-related diseases, including cancer, and senescence has been established. The loss of regenerative and homeostatic capacity of the liver over the age is somehow connected to cellular senescence. The major contributors of senescence properties in the liver are hepatocytes and cholangiocytes. Senescent cells in the liver have been implicated in the etiology of chronic liver diseases including cirrhosis and hepatocellular carcinoma and in the interference of liver regeneration. This review summarizes recently reported findings in the understanding of the molecular mechanisms of senescence and its relationship with liver diseases.
Identifiants
pubmed: 31558857
doi: 10.3748/wjg.v25.i34.5069
pmc: PMC6747293
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5069-5081Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK116605
Pays : United States
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have declared that no conflict of interest exists.
Références
Science. 2000 Feb 18;287(5456):1253-8
pubmed: 10678830
Mol Cell Biol. 2000 Apr;20(8):2803-8
pubmed: 10733583
Genes Dev. 2000 Dec 1;14(23):3037-50
pubmed: 11114892
Hum Pathol. 2001 Mar;32(3):327-32
pubmed: 11274643
J Hepatol. 2001 Apr;34(4):500-6
pubmed: 11394648
FASEB J. 2002 Jul;16(9):935-42
pubmed: 12087054
Cancer Cell. 2002 Aug;2(2):103-12
pubmed: 12204530
Nat Rev Cancer. 2003 Feb;3(2):102-9
pubmed: 12563309
J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):205-11
pubmed: 12634285
Exp Cell Res. 1961 Dec;25:585-621
pubmed: 13905658
Exp Cell Res. 1965 Mar;37:614-36
pubmed: 14315085
FASEB J. 2003 Dec;17(15):2293-5
pubmed: 14500545
EMBO Rep. 2003 Nov;4(11):1061-6
pubmed: 14566323
J Clin Invest. 2004 Nov;114(9):1299-307
pubmed: 15520862
Int J Biochem Cell Biol. 2005 May;37(5):961-76
pubmed: 15743671
Hepatology. 2005 Apr;41(4):809-18
pubmed: 15793848
Exp Gerontol. 2005 Aug-Sep;40(8-9):650-9
pubmed: 16102930
Mol Cancer Res. 2005 Nov;3(11):627-34
pubmed: 16317088
Cell Cycle. 2006 Mar;5(5):506-8
pubmed: 16552188
Aging Cell. 2006 Apr;5(2):187-95
pubmed: 16626397
Cell. 2006 Aug 11;126(3):503-14
pubmed: 16901784
Biochem Biophys Res Commun. 2006 Dec 8;351(1):216-22
pubmed: 17056014
Nature. 2007 Feb 8;445(7128):656-60
pubmed: 17251933
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40
pubmed: 17667954
Exp Cell Res. 2008 Jun 10;314(9):1918-22
pubmed: 18282568
Mol Cell Proteomics. 2008 Sep;7(9):1737-47
pubmed: 18515266
Cell. 2008 Jun 13;133(6):1006-18
pubmed: 18555777
Cell. 2008 Jun 13;133(6):1019-31
pubmed: 18555778
Cell. 2008 Aug 22;134(4):657-67
pubmed: 18724938
Genes Dev. 2009 Apr 1;23(7):798-803
pubmed: 19279323
Gastroenterology. 2010 Mar;138(3):1155-65.e1-2
pubmed: 19919837
Nat Protoc. 2009;4(12):1798-806
pubmed: 20010931
Am J Clin Pathol. 2010 Feb;133(2):212-23
pubmed: 20093230
PLoS One. 2010 Apr 21;5(4):e10231
pubmed: 20422055
Trends Mol Med. 2010 May;16(5):238-46
pubmed: 20444648
Cell. 1990 Jul 13;62(1):175-85
pubmed: 2163767
Annu Rev Cell Biol. 1990;6:597-641
pubmed: 2177343
PLoS One. 2011;6(8):e23367
pubmed: 21858089
J Gastrointest Surg. 2012 Jan;16(1):148-55; discussion 155
pubmed: 22042567
Nature. 2011 Nov 09;479(7374):547-51
pubmed: 22080947
Biochem Biophys Res Commun. 2012 Mar 30;420(1):29-35
pubmed: 22390936
Cell. 2012 Jun 8;149(6):1269-83
pubmed: 22682249
Annu Rev Physiol. 2013;75:685-705
pubmed: 23140366
J Hepatol. 2013 Mar;58(3):549-56
pubmed: 23142622
Methods Mol Biol. 2013;965:63-81
pubmed: 23296651
J Cell Biol. 2013 May 13;201(4):613-29
pubmed: 23649808
Nat Cell Biol. 2013 Aug;15(8):978-90
pubmed: 23770676
Nature. 2013 Jul 4;499(7456):97-101
pubmed: 23803760
J Exp Med. 2013 Sep 23;210(10):2057-69
pubmed: 24043758
Biogerontology. 2013 Dec;14(6):617-28
pubmed: 24114507
Cancer Cell. 2014 Feb 10;25(2):196-209
pubmed: 24486181
Nature. 2014 May 22;509(7501):439-46
pubmed: 24848057
Dev Cell. 2014 Dec 22;31(6):722-33
pubmed: 25499914
Nat Cell Biol. 2015 Aug;17(8):1049-61
pubmed: 26147250
Nat Rev Endocrinol. 2015 Sep;11(9):535-46
pubmed: 26215259
Science. 2015 Sep 25;349(6255):aaa5612
pubmed: 26404840
Nat Rev Immunol. 2015 Dec;15(12):760-70
pubmed: 26603901
Nature. 2016 Jan 7;529(7584):37-42
pubmed: 26738589
Genomics Proteomics Bioinformatics. 2015 Dec;13(6):333-5
pubmed: 26777575
Science. 2015 Dec 4;350(6265):1208-13
pubmed: 26785480
FEBS J. 2016 Jun;283(12):2219-32
pubmed: 26807763
Cancer Discov. 2016 Jun;6(6):612-29
pubmed: 27099234
HPB (Oxford). 2016 Aug;18(8):691-6
pubmed: 27485064
Nat Cell Biol. 2016 Sep;18(9):979-92
pubmed: 27525720
Hepatology. 2017 Feb;65(2):544-559
pubmed: 27639079
Clin Exp Med. 2017 Aug;17(3):269-280
pubmed: 27655446
Cancer Cell. 2016 Oct 10;30(4):533-547
pubmed: 27728804
Hepatology. 2017 Aug;66(2):528-541
pubmed: 28256736
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620
pubmed: 28533362
Cell. 2017 Jun 1;169(6):1000-1011
pubmed: 28575665
Cell Death Dis. 2017 Jun 15;8(6):e2886
pubmed: 28617435
J Hepatol. 2017 Sep;67(3):619-631
pubmed: 28712691
Nat Cell Biol. 2017 Sep;19(9):1061-1070
pubmed: 28759028
Trends Cell Biol. 2017 Nov;27(11):820-832
pubmed: 28822679
Nature. 2017 Oct 19;550(7676):402-406
pubmed: 28976970
Nat Rev Gastroenterol Hepatol. 2018 Feb;15(2):81-95
pubmed: 29184185
Oncotarget. 2017 Dec 22;9(9):8772-8784
pubmed: 29492237
Nat Commun. 2018 Mar 9;9(1):1020
pubmed: 29523787
J Clin Invest. 2018 Apr 2;128(4):1238-1246
pubmed: 29608137
J Clin Invest. 2018 Apr 2;128(4):1217-1228
pubmed: 29608141
J Exp Med. 2018 May 7;215(5):1287-1299
pubmed: 29622565
Lab Invest. 2018 Nov;98(11):1449-1464
pubmed: 29977037
Sci Transl Med. 2018 Aug 15;10(454):
pubmed: 30111642
Hepatology. 2019 May;69(5):2196-2213
pubmed: 30520052
Nature. 2019 Feb;566(7742):73-78
pubmed: 30728521
Nat Cell Biol. 2019 Mar;21(3):397-407
pubmed: 30778219
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7
pubmed: 7568133
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4337-41
pubmed: 7753808
Nature. 1994 Sep 15;371(6494):257-61
pubmed: 8078588
J Biol Chem. 1998 May 29;273(22):13713-8
pubmed: 9593712
Genes Dev. 1998 Aug 1;12(15):2245-62
pubmed: 9694791