Effect of hydroxyethyl starch on acidosis in patients with aluminum phosphide poisoning.
Aluminum Phosphide
Hydroxyethyl Starch
Rice tablet
Journal
Caspian journal of internal medicine
ISSN: 2008-6164
Titre abrégé: Caspian J Intern Med
Pays: Iran
ID NLM: 101523876
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
28
9
2019
pubmed:
29
9
2019
medline:
29
9
2019
Statut:
ppublish
Résumé
Given the fact that various studies have reported the positive effects of hydroxyethyl starch therapy in controlling shock, this study aimed to compare the effects of hydroxyethyl starch on modifying acidosis and treating patients with aluminum phosphide poisoning. This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test. Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05). Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two treatments could be equally effective.
Sections du résumé
BACKGROUND
BACKGROUND
Given the fact that various studies have reported the positive effects of hydroxyethyl starch therapy in controlling shock, this study aimed to compare the effects of hydroxyethyl starch on modifying acidosis and treating patients with aluminum phosphide poisoning.
METHODS
METHODS
This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test.
RESULTS
RESULTS
Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05).
CONCLUSION
CONCLUSIONS
Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two treatments could be equally effective.
Identifiants
pubmed: 31558987
doi: 10.22088/cjim.10.3.271
pmc: PMC6729151
doi:
Types de publication
Journal Article
Langues
eng
Pagination
271-275Déclaration de conflit d'intérêts
There are no conflicts of interest to disclose.
Références
Anesthesiology. 2000 Nov;93(5):1184-7
pubmed: 11046203
Hum Exp Toxicol. 2005 Jan;24(1):27-33
pubmed: 15727053
Clin Toxicol (Phila). 2006;44(2):155-8
pubmed: 16615671
Shock. 2007 May;27(5):520-6
pubmed: 17438457
Clin Toxicol (Phila). 2009 Feb;47(2):89-100
pubmed: 19280425
Crit Care Med. 2010 Feb;38(2):464-70
pubmed: 19789444
Indian J Crit Care Med. 2009 Jan-Mar;13(1):21-4
pubmed: 19881175
Med Hypotheses. 2011 Apr;76(4):596-8
pubmed: 21288649
Arh Hig Rada Toksikol. 2012 Mar;63(1):61-73
pubmed: 22450207
Arh Hig Rada Toksikol. 2012 Dec;63(4):551
pubmed: 23334051
Caspian J Intern Med. 2011 Summer;2(3):286-8
pubmed: 24049589
Arh Hig Rada Toksikol. 2013 Sep;64(3):475-6
pubmed: 24084356
Medicine (Baltimore). 2015 Sep;94(38):e1637
pubmed: 26402837
Acta Med Iran. 2016 Jul;54(7):475-8
pubmed: 27424021
PLoS One. 2017 Apr 5;12(4):e0174507
pubmed: 28380062