Melatonin and the control of intraocular pressure.
Aqueous humor
Glaucoma
Intraocular pressure
Melatonin
Receptor heteromerization
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
03
06
2019
revised:
13
09
2019
accepted:
18
09
2019
pubmed:
29
9
2019
medline:
18
3
2021
entrez:
28
9
2019
Statut:
ppublish
Résumé
Melatonin is not only synthesized by the pineal gland but by several ocular structures. This natural indoleamine is of great importance for regulating several eye processes, among which pressure homeostasis is included. Glaucoma, the most prevalent eye disease, also known as the silent thief of vision, is a multifactorial pathology that is associated to age and, often, to intraocular hypertension (IOP). Indeed IOP is the only modifiable risk factor and as such medications are available to control it; however, novel medications are sought to minimize undesirable side effects. Melatonin and analogues decrease IOP in both normotensive and hypertensive eyes. Melatonin activates its cognate membrane receptors, MT
Identifiants
pubmed: 31560946
pii: S1350-9462(19)30085-0
doi: 10.1016/j.preteyeres.2019.100798
pii:
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100798Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Authors declare no conflict of interests.