Pyoderma gangrenosum in hematologic malignancies: A systematic review.
blood
gammopathy
gangrenosum
hematology
leukemia
lymphoma
myelodysplastic
myeloid
pyoderma
ulcer
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
08
07
2019
revised:
15
08
2019
accepted:
17
09
2019
pubmed:
29
9
2019
medline:
22
1
2021
entrez:
28
9
2019
Statut:
ppublish
Résumé
Pyoderma gangrenosum (PG) is a devastating neutrophilic dermatosis that may be associated with trauma or systemic diseases. The associations, characteristics, and temporal relationship of PG with hematologic malignancies are not well understood. We performed a systematic review of PG associated with hematologic malignancies using data from case reports, case series, and retrospective studies. We searched MEDLINE, EMBASE, Scopus, and Web of Science from each database's inception to December 12, 2018. Two reviewers independently selected studies and extracted data. Two hundred seventy-nine publications met the inclusion criteria (340 cases). Myelodysplastic syndrome (MDS) was the most commonly reported hematologic malignancy associated with PG, followed by monoclonal gammopathy of undetermined significance and acute myeloid leukemia. The mean age of patients was 56.5 years, with males being more common. There was a predominance of the ulcerative PG subtype and multifocal distributions across all hematologic malignancies. The majority of MDS cases preceded PG, which was reversed for MGUS. The data were limited by reporting bias because PG subtypes rely on the rendered diagnosis reported. In addition, the classification for hematologic malignancies has evolved since 1978. Patients with PG should be evaluated for hematologic malignancies, with MDS being the most common.
Sections du résumé
BACKGROUND
BACKGROUND
Pyoderma gangrenosum (PG) is a devastating neutrophilic dermatosis that may be associated with trauma or systemic diseases. The associations, characteristics, and temporal relationship of PG with hematologic malignancies are not well understood.
OBJECTIVE
OBJECTIVE
We performed a systematic review of PG associated with hematologic malignancies using data from case reports, case series, and retrospective studies.
METHODS
METHODS
We searched MEDLINE, EMBASE, Scopus, and Web of Science from each database's inception to December 12, 2018. Two reviewers independently selected studies and extracted data.
RESULTS
RESULTS
Two hundred seventy-nine publications met the inclusion criteria (340 cases). Myelodysplastic syndrome (MDS) was the most commonly reported hematologic malignancy associated with PG, followed by monoclonal gammopathy of undetermined significance and acute myeloid leukemia. The mean age of patients was 56.5 years, with males being more common. There was a predominance of the ulcerative PG subtype and multifocal distributions across all hematologic malignancies. The majority of MDS cases preceded PG, which was reversed for MGUS.
LIMITATIONS
CONCLUSIONS
The data were limited by reporting bias because PG subtypes rely on the rendered diagnosis reported. In addition, the classification for hematologic malignancies has evolved since 1978.
CONCLUSION
CONCLUSIONS
Patients with PG should be evaluated for hematologic malignancies, with MDS being the most common.
Identifiants
pubmed: 31560977
pii: S0190-9622(19)32776-8
doi: 10.1016/j.jaad.2019.09.032
pii:
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1346-1359Informations de copyright
Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.