Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study.

Aged Aged, 80 and over Austria Brain Neoplasms / mortality Female Glioblastoma / mortality Humans Male Neurosurgical Procedures Prognosis Retrospective Studies Risk Factors Treatment Outcome
Adjuvant treatment Biomarker Elderly Glioblastoma multiforme Outcome Resection Treatment-associated morbidity

Journal

World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 23 07 2019
revised: 17 09 2019
accepted: 18 09 2019
pubmed: 29 9 2019
medline: 25 1 2020
entrez: 28 9 2019
Statut: ppublish

Résumé

To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. The study population included 160 patients (mean age, 73.1 ± 5.1 years), and the median contrast-enhancing tumor volume was 31.0 cm Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.

Identifiants

DOI: 10.1016/j.wneu.2019.09.097 PMID: 31561040
pubmed: 31561040
pii: S1878-8750(19)32528-8
doi: 10.1016/j.wneu.2019.09.097
pii:
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e583-e591

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Christoph Schwartz (C)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria. Electronic address: c.schwartz@salk.at.

Alexander Romagna (A)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Harald Stefanits (H)

Department of Neurosurgery, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Georg Zimmermann (G)

Department of Neurology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria.

Barbara Ladisich (B)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Philipp Geiger (P)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Julian Rechberger (J)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Sophie Winkler (S)

Department of Neurosurgery, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Lukas Weiss (L)

Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Gerd Fastner (G)

Department of Radiotherapy and Radio-Oncology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Eugen Trinka (E)

Department of Neurology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Serge Weis (S)

Division of Neuropathology, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Sabine Spiegl-Kreinecker (S)

Department of Neurosurgery, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Jürgen Steinbacher (J)

Division of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Mark McCoy (M)

Division of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Trenkler Johannes (T)

Institute of Neuroradiology, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Andreas Gruber (A)

Department of Neurosurgery, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Behnam Rezai Jahromi (B)

Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Mika Niemelä (M)

Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Peter A Winkler (PA)

Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Niklas Thon (N)

Department of Neurosurgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Régions géographiques › Europe › Autriche › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Diagnostic › Pronostic › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Risks and Benefits of Glioblastoma Resection...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Risks and Benefits of Glioblastoma Resection...