Mild Hyperventilation in Traumatic Brain Injury-Relation to Cerebral Energy Metabolism, Pressure Autoregulation, and Clinical Outcome.
Cerebral energy metabolism
Clinical outcome
Hyperventilation
Neurointensive care
Pressure reactivity
Traumatic brain injury
Journal
World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
14
06
2019
revised:
17
09
2019
accepted:
18
09
2019
pubmed:
29
9
2019
medline:
25
1
2020
entrez:
28
9
2019
Statut:
ppublish
Résumé
Hyperventilation is a controversial treatment in traumatic brain injury (TBI). Prophylactic severe hyperventilation (below 3.3 kPa/25 mm Hg) is generally avoided, due to the risk of cerebral ischemia. Mild hyperventilation (arterial pCO This retrospective study was based on 120 patients with severe TBI treated at the neurointensive care unit, Uppsala University Hospital, Sweden, between 2008 and 2018. Data from cerebral microdialysis (glucose, pyruvate, and lactate), arterial pCO Mild hyperventilation, 4.0-4.5 kPa (30-34 mm Hg), was more frequently used early and the patients were gradually normoventilated. Low pCO These findings support the notion that mild hyperventilation is safe and may improve cerebrovascular reactivity.
Identifiants
pubmed: 31561041
pii: S1878-8750(19)32530-6
doi: 10.1016/j.wneu.2019.09.099
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e567-e575Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.