2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors.

Chromones / chemical synthesis Dose-Response Relationship, Drug Humans Molecular Structure Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors / chemical synthesis Quantitative Structure-Activity Relationship Recombinant Proteins / metabolism
2-Styrylchromone AutoGPA Molecular Operating Environment Monoamine oxidase-A Monoamine oxidase-B Quantitative structure–activity relationship

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
11 2019
Historique:
received: 11 07 2019
revised: 28 08 2019
accepted: 15 09 2019
pubmed: 29 9 2019
medline: 21 10 2020
entrez: 28 9 2019
Statut: ppublish

Résumé

A series of eighteen 2-styrylchromone derivatives (see Chart 1) were synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibitory activities. Many of the derivatives inhibited MAO-B comparable to pargyline (a positive control), and most of them inhibited MAO-B selectively. Of the eighteen derivatives, compound 9 having methoxy group at R

Identifiants

DOI: 10.1016/j.bioorg.2019.103285 PMID: 31561103
pubmed: 31561103
pii: S0045-2068(19)31103-4
doi: 10.1016/j.bioorg.2019.103285
pii:
doi:

Substances chimiques

2-styrylchromone 0
Chromones 0
Monoamine Oxidase Inhibitors 0
Recombinant Proteins 0
Monoamine Oxidase EC 1.4.3.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103285

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Koichi Takao (K)

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan. Electronic address: ktakao@josaiac.jp.

Saki Endo (S)

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan.

Junko Nagai (J)

Department of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

Hitoshi Kamauchi (H)

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan.

Yuri Takemura (Y)

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan.

Yoshihiro Uesawa (Y)

Department of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

Yoshiaki Sugita (Y)

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Relation quantitative structure-activité › 2-Styrylchromone derivatives as potent and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › 2-Styrylchromone derivatives as potent and...