Defects in Axonal Transport in Inherited Neuropathies.
Axonal transport
Charcot-Marie-Tooth
disease
cargoes
cytoskeleton
genetics
inherited peripheral neuropathies
molecular motors
neurodegeneration
therapeutics
Journal
Journal of neuromuscular diseases
ISSN: 2214-3602
Titre abrégé: J Neuromuscul Dis
Pays: Netherlands
ID NLM: 101649948
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
29
9
2019
medline:
14
4
2020
entrez:
29
9
2019
Statut:
ppublish
Résumé
Axonal transport is a highly complex process essential for sustaining proper neuronal functioning. Disturbances can result in an altered neuronal homeostasis, aggregation of cargoes, and ultimately a dying-back degeneration of neurons. The impact of dysfunction in axonal transport is shown by genetic defects in key proteins causing a broad spectrum of neurodegenerative diseases, including inherited peripheral neuropathies. In this review, we provide an overview of the cytoskeletal components, molecular motors and adaptor proteins involved in axonal transport mechanisms and their implication in neuronal functioning. In addition, we discuss the involvement of axonal transport dysfunction in neurodegenerative diseases with a particular focus on inherited peripheral neuropathies. Lastly, we address some recent scientific advances most notably in therapeutic strategies employed in the area of axonal transport, patient-derived iPSC models, in vivo animal models, antisense-oligonucleotide treatments, and novel chemical compounds.
Identifiants
pubmed: 31561383
pii: JND190427
doi: 10.3233/JND-190427
pmc: PMC6918914
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Mitochondrial Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-419Références
Hum Mol Genet. 2019 Feb 15;28(4):615-627
pubmed: 30339187
PLoS One. 2011 Feb 16;6(2):e17087
pubmed: 21359212
Cell Death Dis. 2018 May 22;9(6):596
pubmed: 29789529
J Lipid Res. 2017 Jan;58(1):42-59
pubmed: 27881717
Neuron. 2006 Oct 19;52(2):293-305
pubmed: 17046692
Curr Opin Pharmacol. 2018 Oct;42:102-110
pubmed: 30193150
Redox Biol. 2015;4:6-13
pubmed: 25479550
Cell Stress Chaperones. 2016 Sep;21(5):837-48
pubmed: 27273088
Curr Biol. 2015 May 18;25(10):1282-95
pubmed: 25913400
Mol Neurobiol. 2019 Sep;56(9):6095-6105
pubmed: 30721447
Neurobiol Dis. 2009 Dec;36(3):509-20
pubmed: 19782751
Nat Rev Mol Cell Biol. 2012 Jun 22;13(7):463-70
pubmed: 22722608
Cytoskeleton (Hoboken). 2016 Oct;73(10):521-550
pubmed: 26934450
Brain. 2019 May 1;142(5):1227-1241
pubmed: 30907403
ACS Chem Neurosci. 2015 Apr 15;6(4):666-80
pubmed: 25676389
J Cell Biol. 2013 Apr 29;201(3):361-72
pubmed: 23629963
Brain. 2018 Apr 1;141(4):e28
pubmed: 29529134
Stem Cell Reports. 2018 Feb 13;10(2):375-389
pubmed: 29358088
Pain. 2017 Jun;158(6):1126-1137
pubmed: 28267067
Nat Genet. 2010 Jan;42(1):72-6
pubmed: 20023659
Hum Mol Genet. 2008 May 1;17(9):1245-52
pubmed: 18203753
Dis Model Mech. 2018 Mar 8;11(3):
pubmed: 29469033
Hum Mol Genet. 2017 Oct 1;26(R2):R151-R159
pubmed: 28977438
Hum Genet. 2016 Aug;135(8):851-67
pubmed: 27215579
EMBO Rep. 2011 Jun;12(6):565-73
pubmed: 21508961
Front Neurosci. 2018 May 15;12:326
pubmed: 29867335
J Neurosci. 2013 Sep 25;33(39):15362-75
pubmed: 24068803
Trends Biochem Sci. 2015 Oct;40(10):597-610
pubmed: 26410600
Acta Neuropathol. 2018 Jan;135(1):131-148
pubmed: 28780615
J Neurocytol. 2000 Nov-Dec;29(11-12):843-72
pubmed: 11466475
Am J Hum Genet. 2013 Jun 6;92(6):946-54
pubmed: 23664116
Mol Biol Cell. 2004 Jan;15(1):151-61
pubmed: 14565972
Cell Rep. 2018 Jul 31;24(5):1254-1265
pubmed: 30067980
Hum Mol Genet. 2012 Mar 15;21(6):1299-311
pubmed: 22131369
F1000Res. 2017 Mar 1;6:200
pubmed: 28344778
Cell. 2001 Jun 1;105(5):587-97
pubmed: 11389829
Nat Genet. 2010 Feb;42(2):170-4
pubmed: 20037586
Neuron. 2011 May 12;70(3):441-54
pubmed: 21555071
Clin Genet. 2011 Oct;80(4):305-18
pubmed: 21651512
Neuron. 2014 Feb 5;81(3):536-543
pubmed: 24507191
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3213-8
pubmed: 17360631
Genes Genomics. 2018 Jan;40(1):77-84
pubmed: 29892902
Cell Rep. 2018 Sep 4;24(10):2709-2722
pubmed: 30184504
Neurobiol Dis. 2017 Sep;105:300-320
pubmed: 28238949
Mol Biol Cell. 2001 Aug;12(8):2245-56
pubmed: 11514614
J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):58-67
pubmed: 30018047
J Clin Invest. 2015 Jan;125(1):65-74
pubmed: 25654552
Brain. 2003 Mar;126(Pt 3):590-7
pubmed: 12566280
Hum Mol Genet. 2002 Nov 1;11(23):2837-44
pubmed: 12393795
Am J Hum Genet. 2016 Apr 7;98(4):597-614
pubmed: 27040688
J Cell Biol. 2002 Feb 18;156(4):715-24
pubmed: 11854311
Nat Genet. 2010 Feb;42(2):160-4
pubmed: 20037588
Biochim Biophys Acta. 2016 Jun;1860(6):1247-55
pubmed: 26968460
Mar Drugs. 2016 May 19;14(5):
pubmed: 27213408
J Neurosci. 2016 Mar 16;36(11):3254-67
pubmed: 26985035
Int J Biol Sci. 2016 Jul 18;12(9):1083-92
pubmed: 27570482
Hum Mol Genet. 2006 Jan 15;15(2):347-54
pubmed: 16368711
J Biomed Sci. 2017 Jul 19;24(1):47
pubmed: 28720101
Neuromuscul Disord. 2012 Aug;22(8):699-711
pubmed: 22595202
J Med Chem. 2012 Nov 8;55(21):8979-96
pubmed: 23020671
PLoS One. 2017 Jul 5;12(7):e0180353
pubmed: 28678816
Sci Rep. 2017 Jul 4;7(1):4580
pubmed: 28676641
Nat Rev Mol Cell Biol. 2014 Sep;15(9):615-28
pubmed: 25118718
Muscle Nerve. 2019 Apr;59(4):484-486
pubmed: 30536747
Hum Mol Genet. 2017 Sep 1;26(17):3313-3326
pubmed: 28595321
Brain. 2006 Aug;129(Pt 8):2093-102
pubmed: 16714318
Neural Dev. 2016 Jan 20;11:2
pubmed: 26791407
J Cell Biol. 2019 Jun 3;218(6):1871-1890
pubmed: 31068376
J Cell Sci. 2019 Mar 15;132(6):
pubmed: 30877148
Mol Genet Genomic Med. 2015 Mar;3(2):143-54
pubmed: 25802885
Trends Neurosci. 2013 Nov;36(11):641-51
pubmed: 24035135
Nat Genet. 2010 Feb;42(2):165-9
pubmed: 20037587
J Cell Biol. 2017 Oct 2;216(10):3051-3060
pubmed: 28883039
Eur J Hum Genet. 2017 Sep;25(9):1040-1048
pubmed: 28635954
Neurobiol Dis. 2017 Jun;102:21-37
pubmed: 28237315
Cold Spring Harb Mol Case Stud. 2018 Oct 1;4(5):
pubmed: 30054298
Nat Struct Mol Biol. 2018 Mar;25(3):203-207
pubmed: 29416113
Am J Hum Genet. 2019 Apr 4;104(4):721-730
pubmed: 30929742
N Engl J Med. 2011 Dec 22;365(25):2377-88
pubmed: 22187985
Cell Rep. 2014 Sep 11;8(5):1248-56
pubmed: 25176647
Mol Med Rep. 2015 Apr;11(4):2729-34
pubmed: 25482575
Nature. 2018 Feb 7;554(7691):202-206
pubmed: 29420470
Neurology. 2018 Feb 6;90(6):e518-e524
pubmed: 29321234
J Peripher Nerv Syst. 2017 Sep;22(3):162-171
pubmed: 28485482
Hum Mol Genet. 2018 May 15;27(10):1772-1784
pubmed: 29528393
Neuroscientist. 2014 Feb;20(1):71-81
pubmed: 23912032
Am J Hum Genet. 2011 Aug 12;89(2):219-30
pubmed: 21820098
Front Neurosci. 2015 Nov 05;9:401
pubmed: 26594138
J Cell Biol. 2006 Feb 27;172(5):733-45
pubmed: 16505168
Hum Mol Genet. 2018 Apr 15;27(8):1460-1473
pubmed: 29462293
Brain. 2018 Mar 1;141(3):688-697
pubmed: 29342275
J Cell Biol. 2018 Oct 1;217(10):3480-3496
pubmed: 30126838
Adv Sci (Weinh). 2019 Apr 15;6(11):1900344
pubmed: 31179230
J Clin Invest. 2018 Jan 2;128(1):359-368
pubmed: 29202483
Elife. 2017 Jul 25;6:
pubmed: 28742022
Ann Clin Transl Neurol. 2015 Jun;2(6):623-35
pubmed: 26125038
Front Cell Neurosci. 2018 Mar 14;12:66
pubmed: 29593500
Neuron. 2016 Feb 3;89(3):449-60
pubmed: 26844829
Elife. 2017 Jan 13;6:
pubmed: 28085665
Nat Genet. 2003 Apr;33(4):455-6
pubmed: 12627231
Exp Neurol. 2018 Oct;308:13-25
pubmed: 29940160
Mol Biol Cell. 2008 Jun;19(6):2402-12
pubmed: 18353969
Int J Biochem Cell Biol. 2013 Jul;45(7):1499-508
pubmed: 23618875
Nat Protoc. 2016 Sep;11(9):1711-23
pubmed: 27560175
Neurobiol Dis. 2017 Sep;105:283-299
pubmed: 28235672
J Funct Biomater. 2018 Mar 01;9(1):null
pubmed: 29494503
Nat Commun. 2019 Feb 15;10(1):780
pubmed: 30770803
Nat Neurosci. 2009 May;12(5):559-67
pubmed: 19377471
Annu Rev Biochem. 2007;76:751-80
pubmed: 17362197
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12913-8
pubmed: 17646655
J Exp Med. 2019 Feb 4;216(2):294-303
pubmed: 30642945
J Clin Med. 2018 Dec 22;8(1):null
pubmed: 30583522
Nat Med. 2011 Jul 24;17(8):968-74
pubmed: 21785432
Biol Open. 2014 May 23;3(6):494-502
pubmed: 24857849
Methods Mol Biol. 2019;1994:165-174
pubmed: 31124114
Eur J Cell Biol. 2009 Apr;88(4):193-202
pubmed: 19147253
Int J Mol Sci. 2017 Jan 13;18(1):
pubmed: 28098754
Nat Genet. 2009 Feb;41(2):163-5
pubmed: 19136952
Nat Genet. 2000 Nov;26(3):370-4
pubmed: 11062483
Nat Genet. 2005 Mar;37(3):289-94
pubmed: 15731758
Nat Commun. 2016 Jun 10;7:11808
pubmed: 27283760
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10822-E10829
pubmed: 30366951
Acta Neuropathol Commun. 2017 Jul 14;5(1):55
pubmed: 28709447
Acta Neurol Belg. 2018 Dec;118(4):643-646
pubmed: 30411208
Trends Microbiol. 2015 May;23(5):283-8
pubmed: 25639651
Neurol Genet. 2018 Jun 05;4(3):e244
pubmed: 29888333
Neuron. 2011 May 26;70(4):626-44
pubmed: 21609821
J Clin Invest. 2017 Mar 1;127(3):1005-1018
pubmed: 28192369
Annu Rev Neurosci. 2012;35:25-47
pubmed: 22540978
Biochem Soc Trans. 2017 Aug 15;45(4):1007-14
pubmed: 28710288