Fatal Elephant Endotheliotropic Herpesvirus Infection of Two Young Asian Elephants.
EEHV-1A
cell culture
diagnosis
elephant
gB
herpesvirus
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
26 Sep 2019
26 Sep 2019
Historique:
received:
29
08
2019
revised:
18
09
2019
accepted:
24
09
2019
entrez:
29
9
2019
pubmed:
29
9
2019
medline:
29
9
2019
Statut:
epublish
Résumé
Elephant endotheliotropic herpesvirus (EEHV) can cause a devastating haemorrhagic disease in young Asian elephants worldwide. Here, we report the death of two young Asian elephants after suffering from acute haemorrhagic disease due to EEHV-1A infection. We detected widespread distribution of EEHV-1A in various organs and tissues of the infected elephants. Enveloped viral particles accumulated within and around cytoplasmic electron-dense bodies in hepatic endothelial cells were detected. Attempts to isolate the virus on different cell cultures showed limited virus replication; however, late viral protein expression was detected in infected cells. We further showed that glycoprotein B (gB) of EEHV-1A possesses a conserved cleavage site Arg-X-Lys/Arg-Arg that is targeted by the cellular protease furin, similar to other members of the
Identifiants
pubmed: 31561506
pii: microorganisms7100396
doi: 10.3390/microorganisms7100396
pmc: PMC6843339
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Freie Universität Berlin
ID : Dr. Manfred Semmer
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