Silk Fibroin as a Functional Biomaterial for Drug and Gene Delivery.
bioconjugation
controlled release
drug delivery
gene delivery
silk fibroin
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Sep 2019
26 Sep 2019
Historique:
received:
25
08
2019
revised:
24
09
2019
accepted:
24
09
2019
entrez:
29
9
2019
pubmed:
29
9
2019
medline:
29
9
2019
Statut:
epublish
Résumé
Silk is a natural polymer with unique physicochemical and mechanical properties which makes it a desirable biomaterial for biomedical and pharmaceutical applications. Silk fibroin (SF) has been widely used for preparation of drug delivery systems due to its biocompatibility, controllable degradability and tunable drug release properties. SF-based drug delivery systems can encapsulate and stabilize various small molecule drugs as well as large biological drugs such as proteins and DNA to enhance their shelf lives and control the release to enhance their circulation time in the blood and thus the duration of action. Understanding the properties of SF and the potential ways of manipulating its structure to modify its physicochemical and mechanical properties allows for preparation of modulated drug delivery systems with desirable efficacies. This review will discuss the properties of SF material and summarize the recent advances of SF-based drug and gene delivery systems. Furthermore, conjugation of the SF to other biomolecules or polymers for tissue-specific drug delivery will also be discussed.
Identifiants
pubmed: 31561578
pii: pharmaceutics11100494
doi: 10.3390/pharmaceutics11100494
pmc: PMC6835371
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Engineering and Physical Sciences Research Council
ID : EP/N007174/1 and EP/N023579/1
Organisme : Royal Society
ID : RG160662
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