Lin28b controls a neonatal to adult switch in B cell positive selection.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
27 09 2019
27 09 2019
Historique:
received:
25
03
2019
accepted:
27
08
2019
entrez:
29
9
2019
pubmed:
29
9
2019
medline:
4
6
2020
Statut:
ppublish
Résumé
The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5
Identifiants
pubmed: 31562190
pii: 4/39/eaax4453
doi: 10.1126/sciimmunol.aax4453
pii:
doi:
Substances chimiques
Lin28b protein, mouse
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.