Insights into the non-mitotic functions of Aurora kinase A: more than just cell division.
Animals
Aurora Kinase A
/ analysis
Cell Cycle
/ drug effects
Cell Movement
/ drug effects
Enzyme Activation
/ drug effects
Humans
Microscopy, Fluorescence
Mitochondria
/ drug effects
Mitochondrial Dynamics
/ drug effects
Mitosis
/ drug effects
Neoplasms
/ drug therapy
Protein Kinase Inhibitors
/ pharmacology
Substrate Specificity
AURKA
Cell cycle
FRET
Fluorescence microscopy
Non-mitotic roles
Structural data
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
04
2019
accepted:
18
09
2019
revised:
13
09
2019
pubmed:
29
9
2019
medline:
14
4
2020
entrez:
29
9
2019
Statut:
ppublish
Résumé
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy uncovered several non-mitotic roles as well. In physiological conditions, AURKA regulates cilia disassembly, neurite extension, cell motility, DNA replication and senescence programs. In cancer-like contexts, AURKA actively promotes DNA repair, it acts as a transcription factor, promotes cell migration and invasion, and it localises at mitochondria to regulate mitochondrial dynamics and ATP production. Here we review the non-mitotic roles of AURKA, and its partners outside of cell division. In addition, we give an insight into how structural data and quantitative fluorescence microscopy allowed to understand AURKA activation and its interaction with new substrates, highlighting future developments in fluorescence microscopy needed to better understand AURKA functions in vivo. Last, we will recapitulate the most significant AURKA inhibitors currently in clinical trials, and we will explore how the non-mitotic roles of the kinase may provide new insights to ameliorate current pharmacological strategies against AURKA overexpression.
Identifiants
pubmed: 31562563
doi: 10.1007/s00018-019-03310-2
pii: 10.1007/s00018-019-03310-2
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Aurora Kinase A
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1031-1047Références
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