Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
12-HETE
15-HETE
Blood-brain barrier
Eicosanoid
Hemorrhage
Hemorrhagic transformation
Ischemia
Ischemic stroke
Lipoxygenase
Neuroprotection
STAT6
Tissue plasminogen activator
Warfarin
tPA
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
29
9
2019
pubmed:
29
9
2019
medline:
3
10
2019
Statut:
ppublish
Résumé
Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke.
Identifiants
pubmed: 31562627
doi: 10.1007/978-3-030-21735-8_12
pmc: PMC7278041
mid: NIHMS1582813
doi:
Substances chimiques
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-131Subventions
Organisme : NINDS NIH HHS
ID : R01 NS049430
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS087165
Pays : United States
Organisme : NINDS NIH HHS
ID : UG3 NS106854
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS106854
Pays : United States
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