Kidney transplantation from an HIV-positive cadaveric donor.
AIDS-Associated Nephropathy
/ complications
Adult
Allografts
/ virology
Anti-HIV Agents
/ administration & dosage
Antiretroviral Therapy, Highly Active
/ methods
Donor Selection
/ legislation & jurisprudence
Female
Humans
Italy
Kidney
/ virology
Kidney Failure, Chronic
/ etiology
Kidney Transplantation
/ methods
Male
Middle Aged
Preoperative Care
/ methods
Treatment Outcome
Viral Load
/ drug effects
HIV-infection
HIV-positive donor
kidney transplantation
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
12
05
2019
revised:
26
08
2019
accepted:
14
09
2019
pubmed:
29
9
2019
medline:
1
5
2020
entrez:
29
9
2019
Statut:
ppublish
Résumé
Kidney transplantation is the gold-standard therapy for select HIV-positive patients with ESRD. Since the Italian Ministry of Health defined the guidelines for organ donation from HIV-positive persons in 2018, we report the first case of renal transplantation from an HIV-positive cadaveric donor in two HIV-positive recipients in Italy. The donor was a 50-year-old male, deceased due to post-anoxic encephalopathy, with a history of HIV infection in HAART, undetectable viral load, and HCV-related chronic hepatitis that had been previously treated. The first recipient was a 59-year-old female with a prior history of drug addiction, and she suffered from ESRD secondary to HIV nephropathy. The patient followed preoperative HAART with a good viral response and undetectable HIV viral load. She also had a history of HCV-related chronic hepatitis that had been successfully treated. The right kidney was uneventfully transplanted. The patient developed an asymptomatic reinfection of endogenous BK virus. The second recipient was a 41-year-old male with ESRD secondary to polycystic kidney disease. The patient was HIV-positive in HAART, with a good viro-immunologic response and an undetectable HIV viral load. He suffered from a severe form of hemophilia A and HCV-related chronic hepatitis, which had been previously treated with undetectable HCV RNA. The left kidney was uneventfully transplanted. At the end of follow-up, both patients had a healthy condition with stable renal function, a persistently good viral response and undetectable HIV and HCV viral loads. These encouraging preliminary results seem to confirm the safety and effectiveness of kidney transplantation from select HIV-positive donors.
Substances chimiques
Anti-HIV Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13183Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
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