The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease.

Anti-Glomerular Basement Membrane Disease / drug therapy Bacterial Proteins / therapeutic use Humans Treatment Outcome
IdeS IgG PLEX anti-GBM disease

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
11 2019
Historique:
received: 27 03 2019
revised: 30 05 2019
accepted: 20 06 2019
pubmed: 30 9 2019
medline: 21 10 2020
entrez: 30 9 2019
Statut: ppublish

Résumé

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses into F(ab')

Identifiants

DOI: 10.1016/j.kint.2019.06.019 PMID: 31563334
pubmed: 31563334
pii: S0085-2538(19)30769-0
doi: 10.1016/j.kint.2019.06.019
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Mac-1-like protein, Streptococcus 0

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1234-1238

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Inga Soveri (I)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: inga.soveri@medsci.uu.se.

Johan Mölne (J)

Department of Pathology and Genetics, Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Fredrik Uhlin (F)

Departments of Nephrology and Medical and Health Sciences, Linköping University, Linköping, Sweden; Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.

Thomas Nilsson (T)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Christian Kjellman (C)

Hansa Biopharma, Lund, Sweden.

Elisabeth Sonesson (E)

Hansa Biopharma, Lund, Sweden.

Mårten Segelmark (M)

Departments of Nephrology and Medical and Health Sciences, Linköping University, Linköping, Sweden.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladie des anticorps antimembrane basale glomérulaire › The IgG-degrading enzyme of Streptococcus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › The IgG-degrading enzyme of Streptococcus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The IgG-degrading enzyme of Streptococcus...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › The IgG-degrading enzyme of Streptococcus...