Quantitative investigation of hepatobiliary transport of [

Adult Bile / metabolism Biological Transport Carbon Radioisotopes Cross-Over Studies Healthy Volunteers Humans Injections, Intravenous Liver / chemistry Male Molecular Structure Positron-Emission Tomography Telmisartan / administration & dosage Young Adult
Hepatobiliary transport Integration plot Nonlinear pharmacokinetics Positron emission tomography (PET) Telmisartan

Journal

Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 07 09 2018
revised: 28 12 2018
accepted: 20 02 2019
pubmed: 1 10 2019
medline: 24 3 2020
entrez: 1 10 2019
Statut: ppublish

Résumé

The pharmacokinetics of telmisartan are nonlinear within the clinical dose range. To identify the underlying mechanism of this nonlinearity, we conducted a PET study in healthy subjects using [

Identifiants

DOI: 10.1016/j.dmpk.2019.02.004 PMID: 31564410
pubmed: 31564410
pii: S1347-4367(18)30152-6
doi: 10.1016/j.dmpk.2019.02.004
pii:
doi:

Substances chimiques

Carbon Radioisotopes 0
Telmisartan U5SYW473RQ

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

293-299

Informations de copyright

Copyright © 2019 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

Auteurs

Kazuya Maeda (K)

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

Akihito Ohnishi (A)

Division of Molecular Imaging, Institute of Biomedical Research and Innovation(1), 2-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan.

Masahiro Sasaki (M)

Division of Molecular Imaging, Institute of Biomedical Research and Innovation(1), 2-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan.

Yasuhiko Ikari (Y)

Division of Molecular Imaging, Institute of Biomedical Research and Innovation(1), 2-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan.

Kazuki Aita (K)

Division of Molecular Imaging, Institute of Biomedical Research and Innovation(1), 2-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan.

Yasuyoshi Watanabe (Y)

RIKEN Center for Life Science Technologies and Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan.

Hiroyuki Kusuhara (H)

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

Yuichi Sugiyama (Y)

Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.

Michio Senda (M)

Division of Molecular Imaging, Institute of Biomedical Research and Innovation(1), 2-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan. Electronic address: michio_senda@kcho.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Bile › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Métabolisme › Transport biologique › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Études croisées › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Personnes › Bénévoles › Volontaires sains › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections veineuses › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Système digestif › Foie › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Telmisartan › Quantitative investigation of hepatobiliary...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Quantitative investigation of hepatobiliary...