Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
Binding Sites
Cell Line, Tumor
Chromones
/ chemistry
Crystallography, X-Ray
Humans
Pain Management
Pain Measurement
Patch-Clamp Techniques
Potassium Channels, Tandem Pore Domain
/ chemistry
Protein Binding
Structure-Activity Relationship
Tetrahydronaphthalenes
/ chemistry
Tetrazoles
/ chemistry
Thallium
/ chemistry
Activator
K2P
KCNK10
Pain
Pranlukast
TREK2
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
06
09
2019
accepted:
21
09
2019
pubmed:
1
10
2019
medline:
24
6
2020
entrez:
1
10
2019
Statut:
ppublish
Résumé
TREK2 (KCNK10, K
Identifiants
pubmed: 31564414
pii: S0006-291X(19)31823-6
doi: 10.1016/j.bbrc.2019.09.093
pii:
doi:
Substances chimiques
(5,6,7,8-tetrahydronaphthalen-1-yl)-(2-(1H-tetrazol-5-yl)phenyl)amine
0
Chromones
0
KCNK10 protein, human
0
Potassium Channels, Tandem Pore Domain
0
Tetrahydronaphthalenes
0
Tetrazoles
0
potassium channel protein TREK-1
0
Thallium
AD84R52XLF
pranlukast
TB8Z891092
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-40Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.