Maf expression in human macrophages and lymph node sinus macrophages in patients with esophageal cancer.
Biomarkers, Tumor
/ biosynthesis
Esophageal Neoplasms
/ metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Interferon-gamma
/ biosynthesis
Lymph Nodes
/ metabolism
Macrophages
/ metabolism
Male
Proto-Oncogene Proteins c-maf
/ biosynthesis
Retrospective Studies
Sialic Acid Binding Ig-like Lectin 1
/ biosynthesis
CD169
LySM
Maf
esophageal cancer
macrophage
Journal
Journal of clinical and experimental hematopathology : JCEH
ISSN: 1880-9952
Titre abrégé: J Clin Exp Hematop
Pays: Japan
ID NLM: 101141257
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
1
10
2019
pubmed:
1
10
2019
medline:
7
2
2020
Statut:
ppublish
Résumé
The large Maf transcription factors are expressed in immune cells including macrophages and lymphocytes. To investigate the distribution of Maf expression in human organs, immunostaining for Maf was performed using sections of several human organs. High Maf expression was seen in the nucleus of macrophages in the gastrointestinal tract and lymph node sinus macrophages (LySMs). Then, we assessed whether Maf expression in LySMs was correlated with CD169 expression and the clinical prognosis in patients with esophageal cancer. Maf expression was associated with CD169 expression, but Maf expression in LySMs was not associated with the clinical course in patients with esophageal cancer. We determined which cytokines stimulate Maf expression using cultured macrophages. Immunocytochemistry showed that Maf expression was significantly elevated by interferon-γ. These results are the first report of Maf expression in human samples. Maf expression may be a marker for the macrophage population in humans.
Identifiants
pubmed: 31564713
doi: 10.3960/jslrt.19002
pmc: PMC6798145
doi:
Substances chimiques
Biomarkers, Tumor
0
IFNG protein, human
0
MAF protein, human
0
Proto-Oncogene Proteins c-maf
0
SIGLEC1 protein, human
0
Sialic Acid Binding Ig-like Lectin 1
0
Interferon-gamma
82115-62-6
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-118Références
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