Cell-Cell Mechanical Communication in Cancer.
Mechanotransduction
cell mechanics
extracellular matrix
intercellular force
mechanosensing
Journal
Cellular and molecular bioengineering
ISSN: 1865-5025
Titre abrégé: Cell Mol Bioeng
Pays: United States
ID NLM: 101468590
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
1
10
2019
pubmed:
1
10
2019
medline:
1
10
2019
Statut:
ppublish
Résumé
Communication between cancer cells enables cancer progression and metastasis. While cell-cell communication in cancer has primarily been examined through chemical mechanisms, recent evidence suggests that mechanical communication through cell-cell junctions and cell-ECM linkages is also an important mediator of cancer progression. Cancer and stromal cells remodel the ECM through a variety of mechanisms, including matrix degradation, cross-linking, deposition, and physical remodeling. Cancer cells sense these mechanical environmental changes through cell-matrix adhesion complexes and subsequently alter their tension between both neighboring cells and the surrounding matrix, thereby altering the force landscape within the microenvironment. This communication not only allows cancer cells to communicate with each other, but allows stromal cells to communicate with cancer cells through matrix remodeling. Here, we review the mechanisms of intercellular force transmission, the subsequent matrix remodeling, and the implications of this mechanical communication on cancer progression.
Identifiants
pubmed: 31565083
doi: 10.1007/s12195-018-00564-x
pmc: PMC6764766
mid: NIHMS1516261
pii: 564
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-14Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL127499
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Samantha Schwager, Paul Taufalele, and Cynthia Reinhart-King have no conflicts of interest to disclose.
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