Two-photon microperimetry: sensitivity of human photoreceptors to infrared light.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Sep 2019
01 Sep 2019
Historique:
received:
22
05
2019
revised:
16
07
2019
accepted:
17
07
2019
entrez:
1
10
2019
pubmed:
1
10
2019
medline:
1
10
2019
Statut:
epublish
Résumé
Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders.
Identifiants
pubmed: 31565509
doi: 10.1364/BOE.10.004551
pii: 368129
pmc: PMC6757456
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4551-4567Subventions
Organisme : NEI NIH HHS
ID : R01 EY019312
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY025451
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027387
Pays : United States
Organisme : NEI NIH HHS
ID : R24 EY027283
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025696
Pays : United States
Informations de copyright
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
GP: (P, E), MN: AM2M (E), PS: (P), KK (P), MW (P), KP: Polgenix, Inc. (C, S)
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