Synthesis and biological evaluation of a MraY selective analogue of tunicamycins.

Anti-Bacterial Agents / chemical synthesis Bacterial Proteins / antagonists & inhibitors Cell Line Chemistry Techniques, Synthetic Humans Models, Molecular Molecular Conformation Molecular Structure Structure-Activity Relationship Transferases / antagonists & inhibitors Transferases (Other Substituted Phosphate Groups) Tunicamycin / chemical synthesis
antibacterial nucleoside natural products organic chemistry

Journal

Nucleosides, nucleotides & nucleic acids
ISSN: 1532-2335
Titre abrégé: Nucleosides Nucleotides Nucleic Acids
Pays: United States
ID NLM: 100892832

Informations de publication

Date de publication:
2020
Historique:
pubmed: 1 10 2019
medline: 23 9 2020
entrez: 1 10 2019
Statut: ppublish

Résumé

Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-

Identifiants

DOI: 10.1080/15257770.2019.1649696 PMID: 31566068
pubmed: 31566068
doi: 10.1080/15257770.2019.1649696
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Tunicamycin 11089-65-9
Transferases EC 2.-
Transferases (Other Substituted Phosphate Groups) EC 2.7.8.-
mraY protein, Bacteria EC 2.7.8.13

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

349-364

Auteurs

Kazuki Yamamoto (K)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Toyotaka Sato (T)

Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Yuta Hikiji (Y)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Akira Katsuyama (A)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Takanori Matsumaru (T)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Fumika Yakushiji (F)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Shin-Ichi Yokota (SI)

Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Satoshi Ichikawa (S)

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Transferases (other substituted phosphate groups) › Synthesis and biological evaluation of a MraY...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Tunicamycine › Synthesis and biological evaluation of a MraY...