Development of Chemical Entities Endowed with Potent Fast-Killing Properties against
Antimalarials
/ chemistry
Artemisinins
/ chemistry
Cyclic GMP-Dependent Protein Kinases
/ antagonists & inhibitors
ERG1 Potassium Channel
/ antagonists & inhibitors
Humans
Inhibitory Concentration 50
Mutagenesis, Site-Directed
Plasmodium falciparum
/ drug effects
Protozoan Proteins
/ antagonists & inhibitors
Solubility
Structure-Activity Relationship
Thiazoles
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 10 2019
24 10 2019
Historique:
pubmed:
1
10
2019
medline:
17
6
2020
entrez:
1
10
2019
Statut:
ppublish
Résumé
One of the attractive properties of artemisinins is their extremely fast-killing capability, quickly relieving malaria symptoms. Nevertheless, the unique benefits of these medicines are now compromised by the prolonged parasite clearance times and the increasing frequency of treatment failures, attributed to the increased tolerance of
Identifiants
pubmed: 31566384
doi: 10.1021/acs.jmedchem.9b01099
pmc: PMC6816013
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
ERG1 Potassium Channel
0
KCNH2 protein, human
0
Protozoan Proteins
0
Thiazoles
0
artemisinin
9RMU91N5K2
Cyclic GMP-Dependent Protein Kinases
EC 2.7.11.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9217-9235Subventions
Organisme : Medical Research Council
ID : G1000779
Pays : United Kingdom
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