Stability of clinically relevant depression symptoms in old-age across 11 cohorts: a multi-state study.
ATHLOS project
clinically relevant symptom episode
late-life depression
loneliness
multi-state model
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
accepted:
23
09
2019
pubmed:
1
10
2019
medline:
18
9
2020
entrez:
1
10
2019
Statut:
ppublish
Résumé
To study the temporal dynamics of depression symptom episodes in old-age and the related influence of risk factors. Data from 41 362 old adults (54.61% women; mean age = 75.30, SD = 6.20) from the Ageing Trajectories of Health - Longitudinal Opportunities and Synergies (ATHLOS) project were used. Depressive symptoms were followed over an 18-year period. A multi-state model, comprising three statuses (no depression, new clinically relevant episode of symptoms and episode persistence), was fitted. Multinomial regression was used to study the role of risk factors in status transition. Almost 85% of participants showed no depression, but prevalence became lower over time (B = -0.25, P < 0.001). New episode point prevalence was over 5.30% with a significant probability of moving to persistence status (transition probability = 0.27). Episode persistence became evident in 9.86% of episode status transitions, with increasing rate over time (B = 0.54, P < 0.01). Loneliness was proven to be the strongest predictor of episode emergence (OR = 17.76) and persistence (OR = 5.93). The course of depression tends to become chronic and unremitting in old-age. This study may help to plan interventions to tackle symptom escalation and risk factor influence.
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
541-551Subventions
Organisme : European Commission Horizon 2020
ID : 635316
Pays : International
Organisme : NIA NIH HHS
ID : U01 AG009740
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018016
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG005842
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG025169
Pays : United States
Organisme : NIA NIH HHS
ID : HHSN271201300071C
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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