Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Journal
European journal of gastroenterology & hepatology
ISSN: 1473-5687
Titre abrégé: Eur J Gastroenterol Hepatol
Pays: England
ID NLM: 9000874
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
1
10
2019
medline:
29
6
2021
entrez:
1
10
2019
Statut:
ppublish
Résumé
Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) could be a predisposing factor for nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. A comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through September 2018 to identify all studies that compared the risk of NAFLD among patients with SIBO versus those without SIBO. Effect estimates from each study were extracted and combined together using the random effect, generic inverse variance method of DerSimonian and Laird. A total of 10 studies with 1093 participants fulfilled the eligibility criteria and were included in the meta-analysis. A significant association between NAFLD and SIBO was observed with the pooled odds ratio of 3.82 (95% confidence interval, 1.93-7.59; I 65%). Funnel plot is relatively symmetric and is not suggestive of the presence of publication bias. A significant association between NAFLD and SIBO was observed in this meta-analysis.
Identifiants
pubmed: 31567712
doi: 10.1097/MEG.0000000000001541
pii: 00042737-202005000-00010
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-608Références
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