Systems biology based drug repositioning for development of cancer therapy.
Cancer
Drug repositioning
Network-based approaches
Signature-based approaches
Systems biology
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
22
07
2019
revised:
23
09
2019
accepted:
24
09
2019
pubmed:
1
10
2019
medline:
1
3
2022
entrez:
1
10
2019
Statut:
ppublish
Résumé
Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significantly reduce quality of life, drug repositioning promises repurposed noncancer drugs with little or tolerable adverse effects for cancer patients. Here, we review current drug-related data types and databases including some examples of web-based drug repositioning tools. Next, we describe systems biology approaches to be used in drug repositioning for effective cancer therapy. Finally, we highlight examples of mostly repurposed drugs for cancer treatment and provide an overview of future expectations in the field for development of effective treatment strategies.
Identifiants
pubmed: 31568815
pii: S1044-579X(19)30265-2
doi: 10.1016/j.semcancer.2019.09.020
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-58Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.