In vivo toxicity assessment of Clinopodium vulgare L. water extract characterized by UHPLC-HRMS.
Caffeic acid oligomers
Clinopodium vulgare L.
Toxicity
UHPLC-HRMS profiling
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
27
05
2019
revised:
20
09
2019
accepted:
24
09
2019
pubmed:
1
10
2019
medline:
18
2
2020
entrez:
1
10
2019
Statut:
ppublish
Résumé
Clinopodium vulgare L. (Lamiaceae) was used in the traditional Bulgarian medicine for treatment of wounds, diabetes and gastric ulcers. In this study we aimed at safety assessment of C. vulgare lyophilized water extract (CVE) characterized by ultra high-performance liquid chromatography-Orbitrap high resolution mass spectrometry (UHPLC-HRMS). The acute and sub-acute toxicity of CVE was determined in two rodent species (mice and rats), and two routes of administration - intraperitoneal (i.p.) and oral (p.o.). LD
Identifiants
pubmed: 31568851
pii: S0278-6915(19)30631-3
doi: 10.1016/j.fct.2019.110841
pii:
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110841Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.