Synthesis, activity, and molecular modeling studies of 1,2,3-triazole derivatives from natural phenylpropanoids as new trypanocidal agents.
Animals
Biological Products
/ chemistry
Chagas Disease
/ drug therapy
Cysteine Endopeptidases
Cysteine Proteinase Inhibitors
/ chemical synthesis
Disease Models, Animal
Drug Design
Humans
Mice
Molecular Docking Simulation
Molecular Structure
Protozoan Proteins
/ antagonists & inhibitors
Structure-Activity Relationship
Triazoles
/ chemical synthesis
Trypanocidal Agents
/ chemical synthesis
Trypanosoma cruzi
/ drug effects
1,2,3-triazoles
cruzain inhibitors
di-hydroeugenol
eugenol
trypanocidal activity
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
22
05
2019
revised:
12
08
2019
accepted:
21
09
2019
pubmed:
1
10
2019
medline:
29
1
2021
entrez:
1
10
2019
Statut:
ppublish
Résumé
The search for compounds with new structural scaffolds is an important tool to the discovery of new drugs against Chagas disease. We report herein the synthesis of 1,2,3-triazoles obtained from eugenol and di-hydroeugenol and their in vitro and in vivo trypanocidal activity. These derivatives were obtained by a three-step objective route and were suitably characterized by
Substances chimiques
Biological Products
0
Cysteine Proteinase Inhibitors
0
Protozoan Proteins
0
Triazoles
0
Trypanocidal Agents
0
Cysteine Endopeptidases
EC 3.4.22.-
cruzipain
EC 3.4.22.51
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
124-129Informations de copyright
© 2019 John Wiley & Sons Ltd.
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